Modification of the gluconeogenesis is not involved in the co-planar PCB toxicity in highly sensitive guinea pigs

Kazuta Oguri, Megumu Hatsumura, Yuji Ishii, Yoshiko Koga, Noritaka Ariyoshi, Hidetoshi Yoshimura

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Effect of a co-planar PCB, 3,4,5,3′,4′-pentachlorobiphenyl (PenCB) on gluconeogenesis in guinea pigs was compared with that in rats. The key enzyme of gluconeogenesis, phosphoenolpyruvate carboxykinase (PEPCK), in liver cytosol of rats was reduced by PenCB treatment to about 50% of control level. Hypoglycemia was also seen in the rat. On the contrary, the liver cytosol PEPCK activity in guinea pigs was slightly increased by PenCB treatment. Plasma levels of alanine and tryptophan were increased in the rat treated with PenCB, but the level of glycogenic amino acid, alanine, was not raised significantly in the guinea pig. Thus the modification of the gluconeogenesis was not involved in the PenCB toxicity in highly sensitive guinea pigs.

Original languageEnglish
Pages (from-to)2295-2303
Number of pages9
JournalChemosphere
Volume27
Issue number11
DOIs
Publication statusPublished - Dec 1993
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Modification of the gluconeogenesis is not involved in the co-planar PCB toxicity in highly sensitive guinea pigs'. Together they form a unique fingerprint.

  • Cite this