Modification of Helicobacter pylori adhesion to human gastric epithelial cells by antiadhesion agents

S. Hayashi, T. Sugiyama, M. Asaka, K. Yokota, K. Oguma, Y. Hirai

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Helicobacter pylori is a major etiological agent in gastroduodenal disorders. H. pylori adhesion to human gastric mucosa is the initial step of H. pylori colonization. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We have previously established a method using the enzyme-linked immunosorbent assay to analyze quantitatively H. pylori adhesion to gastric epithelial cells. This method is suitable for screening antiadhesion agents. Some mucoprotective agents are proved to have antiadhesion effects in vitro, and they may modify H. pylori adhesion. This evidence gives us a useful clue to analyze the molecular mechanism of H. pylori adhesion to mucosa. Furthermore, in clinical trials, these mucoprotective agents enhanced the eradication rate when administered with antibiotics. In conclusion, the antiadhesion agents may have potential as therapeutic regimens against H. pylori infection.

Original languageEnglish
Pages (from-to)56S-60S
JournalDigestive Diseases and Sciences
Volume43
Issue number9 SUPPL.
Publication statusPublished - Oct 3 1998
Externally publishedYes

Keywords

  • Adhesion
  • Antiadhesion agents
  • Gastric epithelial cells
  • Helicobacter pylori

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Modification of Helicobacter pylori adhesion to human gastric epithelial cells by antiadhesion agents'. Together they form a unique fingerprint.

Cite this