Modification of apatite materials for bone tissue engineering and drug delivery carriers

Takuya Matsumoto, M. Okazaki, A. Nakahira, J. Sasaki, H. Egusa, T. Sohmura

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Apatite-related calcium phosphate, the main component of biological hard tissue, has good biocompatibility and is an economical material. Methods for the synthesis of apatite materials including hydroxyapatite (HAp) have previously been established. Therefore, for many years, apatite materials have been utilized as substitute materials for bone in orthopedic and dental fields. Such types of conventional substitute materials, which are implanted in the human body, should ostensibly be chemically stable to maintain their quality over time. However, recent advances in tissue engineering have altered this concept. Physicians and researchers now seek to identify materials that alter their properties temporally and spatially to achieve ideal tissue regeneration. In order to use apatite materials for tissue engineering and as drug delivery systems, the materials require both a high affinity for cells, tissues and/or functional molecules (e.g. growth factors and genes) and controllable bioabsorbability. To achieve these properties, various physicochemical modifications of apatite materials have been attempted. In addition, fabrication desiring three-dimensional structures (e.g. size, morphology and porosity) of apatite materials for implant sites could be one of the crucial techniques used to obtain ideal prognoses. In this review, the latest research trends relating to the techniques for the fabrication and modification of apatite materials are introduced.

Original languageEnglish
Pages (from-to)2726-2733
Number of pages8
JournalCurrent Medicinal Chemistry
Volume14
Issue number25
DOIs
Publication statusPublished - Oct 2007
Externally publishedYes

Fingerprint

Apatites
Drug Carriers
Tissue Engineering
Drug delivery
Tissue engineering
Bone
Bone and Bones
Bone Substitutes
Porosity
Durapatite
Drug Delivery Systems
Human Body
Orthopedics
Tissue
Regeneration
Intercellular Signaling Peptides and Proteins
Tooth
Fabrication
Tissue regeneration
Research Personnel

Keywords

  • Apatite
  • Bone tissue engineering
  • Cell therapy
  • Drug delivery system
  • Gene therapy
  • Molecular therapy

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

Modification of apatite materials for bone tissue engineering and drug delivery carriers. / Matsumoto, Takuya; Okazaki, M.; Nakahira, A.; Sasaki, J.; Egusa, H.; Sohmura, T.

In: Current Medicinal Chemistry, Vol. 14, No. 25, 10.2007, p. 2726-2733.

Research output: Contribution to journalArticle

Matsumoto, Takuya ; Okazaki, M. ; Nakahira, A. ; Sasaki, J. ; Egusa, H. ; Sohmura, T. / Modification of apatite materials for bone tissue engineering and drug delivery carriers. In: Current Medicinal Chemistry. 2007 ; Vol. 14, No. 25. pp. 2726-2733.
@article{1a8e4e08ec1c4fb8a4a7a03ca93e6fd2,
title = "Modification of apatite materials for bone tissue engineering and drug delivery carriers",
abstract = "Apatite-related calcium phosphate, the main component of biological hard tissue, has good biocompatibility and is an economical material. Methods for the synthesis of apatite materials including hydroxyapatite (HAp) have previously been established. Therefore, for many years, apatite materials have been utilized as substitute materials for bone in orthopedic and dental fields. Such types of conventional substitute materials, which are implanted in the human body, should ostensibly be chemically stable to maintain their quality over time. However, recent advances in tissue engineering have altered this concept. Physicians and researchers now seek to identify materials that alter their properties temporally and spatially to achieve ideal tissue regeneration. In order to use apatite materials for tissue engineering and as drug delivery systems, the materials require both a high affinity for cells, tissues and/or functional molecules (e.g. growth factors and genes) and controllable bioabsorbability. To achieve these properties, various physicochemical modifications of apatite materials have been attempted. In addition, fabrication desiring three-dimensional structures (e.g. size, morphology and porosity) of apatite materials for implant sites could be one of the crucial techniques used to obtain ideal prognoses. In this review, the latest research trends relating to the techniques for the fabrication and modification of apatite materials are introduced.",
keywords = "Apatite, Bone tissue engineering, Cell therapy, Drug delivery system, Gene therapy, Molecular therapy",
author = "Takuya Matsumoto and M. Okazaki and A. Nakahira and J. Sasaki and H. Egusa and T. Sohmura",
year = "2007",
month = "10",
doi = "10.2174/092986707782023208",
language = "English",
volume = "14",
pages = "2726--2733",
journal = "Current Medicinal Chemistry",
issn = "0929-8673",
publisher = "Bentham Science Publishers B.V.",
number = "25",

}

TY - JOUR

T1 - Modification of apatite materials for bone tissue engineering and drug delivery carriers

AU - Matsumoto, Takuya

AU - Okazaki, M.

AU - Nakahira, A.

AU - Sasaki, J.

AU - Egusa, H.

AU - Sohmura, T.

PY - 2007/10

Y1 - 2007/10

N2 - Apatite-related calcium phosphate, the main component of biological hard tissue, has good biocompatibility and is an economical material. Methods for the synthesis of apatite materials including hydroxyapatite (HAp) have previously been established. Therefore, for many years, apatite materials have been utilized as substitute materials for bone in orthopedic and dental fields. Such types of conventional substitute materials, which are implanted in the human body, should ostensibly be chemically stable to maintain their quality over time. However, recent advances in tissue engineering have altered this concept. Physicians and researchers now seek to identify materials that alter their properties temporally and spatially to achieve ideal tissue regeneration. In order to use apatite materials for tissue engineering and as drug delivery systems, the materials require both a high affinity for cells, tissues and/or functional molecules (e.g. growth factors and genes) and controllable bioabsorbability. To achieve these properties, various physicochemical modifications of apatite materials have been attempted. In addition, fabrication desiring three-dimensional structures (e.g. size, morphology and porosity) of apatite materials for implant sites could be one of the crucial techniques used to obtain ideal prognoses. In this review, the latest research trends relating to the techniques for the fabrication and modification of apatite materials are introduced.

AB - Apatite-related calcium phosphate, the main component of biological hard tissue, has good biocompatibility and is an economical material. Methods for the synthesis of apatite materials including hydroxyapatite (HAp) have previously been established. Therefore, for many years, apatite materials have been utilized as substitute materials for bone in orthopedic and dental fields. Such types of conventional substitute materials, which are implanted in the human body, should ostensibly be chemically stable to maintain their quality over time. However, recent advances in tissue engineering have altered this concept. Physicians and researchers now seek to identify materials that alter their properties temporally and spatially to achieve ideal tissue regeneration. In order to use apatite materials for tissue engineering and as drug delivery systems, the materials require both a high affinity for cells, tissues and/or functional molecules (e.g. growth factors and genes) and controllable bioabsorbability. To achieve these properties, various physicochemical modifications of apatite materials have been attempted. In addition, fabrication desiring three-dimensional structures (e.g. size, morphology and porosity) of apatite materials for implant sites could be one of the crucial techniques used to obtain ideal prognoses. In this review, the latest research trends relating to the techniques for the fabrication and modification of apatite materials are introduced.

KW - Apatite

KW - Bone tissue engineering

KW - Cell therapy

KW - Drug delivery system

KW - Gene therapy

KW - Molecular therapy

UR - http://www.scopus.com/inward/record.url?scp=35748960233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35748960233&partnerID=8YFLogxK

U2 - 10.2174/092986707782023208

DO - 10.2174/092986707782023208

M3 - Article

C2 - 17979722

AN - SCOPUS:35748960233

VL - 14

SP - 2726

EP - 2733

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

SN - 0929-8673

IS - 25

ER -