Models for studying DNA methylation in human cancer: A review of current status

Shinichi Toyooka, Nobuyoshi Shimizu

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

In cancer epigenetics, aberrant methylation in the promoter is one of the key mechanisms for gene inactivation resulting in carcinogenesis in humans. Unique models have been utilized for studying methylation, for example, to determine the methylation profile, to study the mechanisms of methylation, and to investigate therapeutic interventions against cancer In humans. It is considered that further development of would be highly useful for further understanding and controlling cancer in humans.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalDrug Discovery Today: Disease Models
Volume1
Issue number1
DOIs
Publication statusPublished - Oct 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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