MK-801 fails to modify the effect of methamphetamine on dopamine release in the rat striatum

Kenichi Kashihara, Kazuya Okumura, Masaru Onishi, Saburo Otsuki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effect of MK-801 at a dose of 0.5 mg kg-1, i.p., on methamphetamine-induced (MAP; 4 mg kg-1, i.p.) dopamine (DA) release was examined in the striatum of freely moving rats using an in-vivo microdialysis method. Combined treatment of MK-801 with MAP did not modify the MAP-induced increase in extracellular DA levels or the decrease in 3,4-dihydroxyphenylacetic acid levels. These findings suggest that MK-801 fails to modify the acute effect of MAP on DA release in the striatum. The blocking effect of MK-801 on the development of MAP-induced behavioral sensitization is unlikely to be mediated by DA neurons.

Original languageEnglish
Pages (from-to)236-238
Number of pages3
JournalNeuroReport
Volume2
Issue number5
Publication statusPublished - 1991

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Dizocilpine Maleate
Methamphetamine
Dopamine
3,4-Dihydroxyphenylacetic Acid
Dopaminergic Neurons
Microdialysis

Keywords

  • Dopamine
  • Methamphetamine
  • Microdialysis
  • Mk-801
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

MK-801 fails to modify the effect of methamphetamine on dopamine release in the rat striatum. / Kashihara, Kenichi; Okumura, Kazuya; Onishi, Masaru; Otsuki, Saburo.

In: NeuroReport, Vol. 2, No. 5, 1991, p. 236-238.

Research output: Contribution to journalArticle

Kashihara, K, Okumura, K, Onishi, M & Otsuki, S 1991, 'MK-801 fails to modify the effect of methamphetamine on dopamine release in the rat striatum', NeuroReport, vol. 2, no. 5, pp. 236-238.
Kashihara, Kenichi ; Okumura, Kazuya ; Onishi, Masaru ; Otsuki, Saburo. / MK-801 fails to modify the effect of methamphetamine on dopamine release in the rat striatum. In: NeuroReport. 1991 ; Vol. 2, No. 5. pp. 236-238.
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