MK-801 fails to modify the effect of methamphetamine on dopamine release in the rat striatum

Kenichi Kashihara, Kazuya Okumura, Masaru Onishi, Saburo Otsuki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effect of MK-801 at a dose of 0.5 mg kg-1, i.p., on methamphetamine-induced (MAP; 4 mg kg-1, i.p.) dopamine (DA) release was examined in the striatum of freely moving rats using an in-vivo microdialysis method. Combined treatment of MK-801 with MAP did not modify the MAP-induced increase in extracellular DA levels or the decrease in 3,4-dihydroxyphenylacetic acid levels. These findings suggest that MK-801 fails to modify the acute effect of MAP on DA release in the striatum. The blocking effect of MK-801 on the development of MAP-induced behavioral sensitization is unlikely to be mediated by DA neurons.

Original languageEnglish
Pages (from-to)236-238
Number of pages3
JournalNeuroReport
Volume2
Issue number5
DOIs
Publication statusPublished - May 1991

Keywords

  • Dopamine
  • Methamphetamine
  • Microdialysis
  • Mk-801
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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