Mizoribine, tacrolimus, and corticosteroid combination therapy successfully induces remission in patients with lupus nephritis

Hidetoshi Kagawa, Tsutomu Hiromasa, Takayuki Hara, Ayako Takaki, Ryutaro Yamanaka, Ken Ei Sada, Hirofumi Makino

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11 Citations (Scopus)

Abstract

Background Conventional cyclophosphamide-based treatment regimens for lupus nephritis (LN) are still not considered to be optimal. The aim of this study was to evaluate the efficacy and safety of mizoribine, tacrolimus, and corticosteroid combination therapy for LN. Methods We retrospectively evaluated a combination treatment of mizoribine and tacrolimus with corticosteroids as induction therapy in eight newly diagnosed systemic lupus erythematosus (SLE) patients with biopsy-proven LN. Results All patients were women, and their mean [standard deviation (SD)] age was 48.5 (20) years. All patients (100 %) had positive anti-double-stranded DNA (antidsDNA) antibody titers, and four (50.0 %) were nephrotic. Mean (SD) serum creatinine and daily proteinuria levels were 0.72 (0.4) mg/dl (range 0.33-1.55 mg/dl) and 4.56 (2.8) g (range 0.77-8.2 g), respectively. By month 2, significant improvements in the anti-dsDNA antibody titers, levels of proteinuria, serum albumin, and C3, and SLE disease activity index score were observed. By month 6, seven patients (87.5 %) were in complete remission, with normalized levels of both proteinuria and serum creatinine. Conclusions This pilot study suggests that mizoribine and tacrolimus treatment with corticosteroids is well tolerated and may prove to be an optimal alternative remissioninducing regimen for LN.

Original languageEnglish
Pages (from-to)760-766
Number of pages7
JournalClinical and Experimental Nephrology
Volume16
Issue number5
DOIs
Publication statusPublished - Oct 1 2012

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Keywords

  • Induction therapy
  • Lupus nephritis
  • Mizoribine
  • Multitarget therapy
  • Systemic lupus erythematosus
  • Tacrolimus

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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