Mixed lymphocyte-tumor cell reaction between remission lymphocytes and autochthonous leukemia cells and its relationship to the prognosis of acute leukemia

R. Ohno, K. Ezaki, Y. Kodera, M. Tanimoto, K. Yamada

Research output: Contribution to journalArticle

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Abstract

The mixed lymphocyte-tumor cell reaction (MLTR) between peripheral lymphocytes and cryopreserved autochthonous leukemia cells was studied in 36 adult patients with acute leukemia after complete remission as a result of chemotherapy. In 20 patients the lymphocytes showed a significant blastogenic response to autochthonous leukemia cells. Eleven out of 18 patients with acute myeloblastic leukemia and 4 out of 5 with acute monocytic leukemia showed positive MLTR, whereas 5 out of 13 with acute lymphoblastic leukemia gave a positive reaction. Cryopreserved leukemia cells of the patients with not only positive but also negative MLTR were able to stimulate allogeneic lymphocytes, except in one case. The relationship between MLTR and the prognosis of leukemia was analyzed in 30 patients who were alive more than 6 months after diagnosis. No apparent correlation was observed between MLTR and the survival time from diagnosis.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalGann, The Japanese Journal of Cancer Research
Volume71
Issue number4
Publication statusPublished - 1980
Externally publishedYes

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Leukemia
Lymphocytes
Neoplasms
Leukemia, Monocytic, Acute
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Cell Survival
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research

Cite this

Mixed lymphocyte-tumor cell reaction between remission lymphocytes and autochthonous leukemia cells and its relationship to the prognosis of acute leukemia. / Ohno, R.; Ezaki, K.; Kodera, Y.; Tanimoto, M.; Yamada, K.

In: Gann, The Japanese Journal of Cancer Research, Vol. 71, No. 4, 1980, p. 451-456.

Research output: Contribution to journalArticle

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AU - Yamada, K.

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