Mitochondrial localization in mouse oocytes

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Intracellular distribution of mitochondria varies during development of the oocyte into a fertilizable egg. Here we demonstrate a change in the distribution of mitochondria during oocyte growth and maturation in living mouse oocytes. In growing oocytes, mitochondria concentrated into subcortical and perinuclear areas, whereas it diffusely distributed throughout the cytoplasm in fully-grown oocytes, indicating the variation of mitochondrial distribution in the same G2/M cell-cycle stages. GFP-labeled mitochondria reveal that oocyte maturation involves dynamic reorganization of the mitochondria, and whose process is associated with microtubule organization. These spatio-temporal regulations of mitochondria in oocytes may be important process in the preparation of fertilization and subsequent embryonic development.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalJournal of Mammalian Ova Research
Volume29
Issue number4
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Oocytes
Mitochondria
Fertilization
Microtubules
Embryonic Development
Ovum
Cell Cycle
Cytoplasm
Growth

Keywords

  • Cytoskeletal organization
  • Mitochondrial localization
  • Mouse
  • Oocyte

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

Cite this

Mitochondrial localization in mouse oocytes. / Wakai, Takuya.

In: Journal of Mammalian Ova Research, Vol. 29, No. 4, 2012, p. 155-160.

Research output: Contribution to journalArticle

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