Mitochondrial dynamics and mitochondrial dysfunction in diabetes

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions. In obesity and type 2 diabetes, impaired oxidation, reduced mitochondrial contents, lowered rates of oxidative phosphorylation and excessive reactive oxygen species (ROS) production have been reported. Mitochondrial biogenesis is regulated by various transcription factors such as peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), peroxisome proliferator-activated receptors (PPARs), estrogen-related receptors (ERRs), and nuclear respiratory factors (NRFs). Mitochondrial fusion is promoted by mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1), while fission is governed by the recruitment of dynamin-related protein 1 (DRP1) by adaptor proteins such as mitochondrial fission factor (MFF), mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51), and fission 1 (FIS1). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARKIN promote DRP1-dependent mitochondrial fission, and the outer mitochondrial adaptor MiD51 is required in DRP1 recruitment and PARKIN-dependent mitophagy. This review describes the molecular mechanism of mitochondrial dynamics, its abnormality in diabetes and obesity, and pharmaceuticals targeting mitochondrial biogenesis, fission, fusion and mitophagy.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalActa Medica Okayama
Volume70
Issue number3
Publication statusPublished - 2016

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Mitochondrial Dynamics
Medical problems
Dynamins
Mitochondrial Degradation
Peroxisome Proliferator-Activated Receptors
Fusion reactions
Nuclear Respiratory Factors
Organelle Biogenesis
Proteins
Mitochondria
Mitochondrial Proteins
Phosphoric Monoester Hydrolases
Autosomal Dominant Optic Atrophy
Obesity
Reactive Oxygen Species
Optics
Estrogens
Transcription Factors
Phosphotransferases
Oxidative Phosphorylation

Keywords

  • Diabetes
  • Fission
  • Fusion
  • Mitochondria
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mitochondrial dynamics and mitochondrial dysfunction in diabetes. / Wada, Jun; Nakatsuka, Atsuko.

In: Acta Medica Okayama, Vol. 70, No. 3, 2016, p. 151-158.

Research output: Contribution to journalReview article

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