Mitochondrial determinants of mammalian longevity

Yasuhiro Kitazoe, Masami Hasegawa, Masashi Tanaka, Midori Futami, Junichiro Futami

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Current ageing theories are far from satisfactory because of the many determinants involved in ageing. The well-known rate-of-living theory assumes that the product (lifetime energy expenditure, LEE) of maximum lifespan (MLS) and mass-specific basal metabolic rate (msBMR) is approximately constant. Although this theory provides a significant inverse correlation between msBMR and MLS as a whole for mammals, it remains problematic for two reasons. First, several interspecies studies within respective orders (typically within rodents) have shown no inverse relationships between msBMR and MLS. Second, LEE values widely vary in mammals and birds. Here, to solve these two problems, we introduced a new quantity designated asmitochondrial (mt) lifetime energy output, mtLEO = MLS × mtMR, in place of LEE, by using the mt metabolic rate (mtMR) per mitochondrion. Thereby, we found that mtLEO valueswere distributedmore narrowly than LEE ones, and strongly correlated with the four amino-acid variables (AAVs) of Ser, Thr and Cys contents and hydrophobicity of mtDNA-encoded membrane proteins (these variables were related to the stability of these proteins). Consequently, only these two mt items, mtMR and the AAVs, solved the above-mentioned problems in the rateof- living theory, and thus extensively improved the correlation with MLS compared with that given by LEE.

Original languageEnglish
Article number170083
JournalOpen Biology
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 1 2017

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Energy Metabolism
Basal Metabolism
Mammals
Aging of materials
Amino Acids
Mitochondria
Protein Stability
Birds
Hydrophobicity
Mitochondrial DNA
Hydrophobic and Hydrophilic Interactions
Rodentia
Membrane Proteins
Proteins

Keywords

  • Ageing theory
  • Mammalian longevity
  • Metabolic rate
  • Mitochondrial membrane proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kitazoe, Y., Hasegawa, M., Tanaka, M., Futami, M., & Futami, J. (2017). Mitochondrial determinants of mammalian longevity. Open Biology, 7(10), [170083]. https://doi.org/10.1098/rsob.170083

Mitochondrial determinants of mammalian longevity. / Kitazoe, Yasuhiro; Hasegawa, Masami; Tanaka, Masashi; Futami, Midori; Futami, Junichiro.

In: Open Biology, Vol. 7, No. 10, 170083, 01.10.2017.

Research output: Contribution to journalArticle

Kitazoe, Y, Hasegawa, M, Tanaka, M, Futami, M & Futami, J 2017, 'Mitochondrial determinants of mammalian longevity', Open Biology, vol. 7, no. 10, 170083. https://doi.org/10.1098/rsob.170083
Kitazoe Y, Hasegawa M, Tanaka M, Futami M, Futami J. Mitochondrial determinants of mammalian longevity. Open Biology. 2017 Oct 1;7(10). 170083. https://doi.org/10.1098/rsob.170083
Kitazoe, Yasuhiro ; Hasegawa, Masami ; Tanaka, Masashi ; Futami, Midori ; Futami, Junichiro. / Mitochondrial determinants of mammalian longevity. In: Open Biology. 2017 ; Vol. 7, No. 10.
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