MiRNA expression atlas in male rat

Keiichi Minami, Takeki Uehara, Yuji Morikawa, Ko Omura, Masayuki Kanki, Akira Horinouchi, Atsushi Ono, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small (∼22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset.

Original languageEnglish
Article number140005
JournalScientific Data
Volume1
DOIs
Publication statusPublished - May 27 2014
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Information Systems
  • Education
  • Computer Science Applications
  • Statistics, Probability and Uncertainty
  • Library and Information Sciences

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    Minami, K., Uehara, T., Morikawa, Y., Omura, K., Kanki, M., Horinouchi, A., Ono, A., Yamada, H., Ohno, Y., & Urushidani, T. (2014). MiRNA expression atlas in male rat. Scientific Data, 1, [140005]. https://doi.org/10.1038/sdata.2014.5