MiRNA expression atlas in male rat

Keiichi Minami, Takeki Uehara, Yuji Morikawa, Ko Omura, Masayuki Kanki, Akira Horinouchi, Atsushi Ono, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small (∼22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset.

Original languageEnglish
Article number140005
JournalScientific data
Volume1
DOIs
Publication statusPublished - May 27 2014
Externally publishedYes

Fingerprint

MicroRNA
Atlases
Atlas
role play
MicroRNAs
Rats
Japan
Tissue
regulation
Biomarkers
Values
Nucleotides
RNA
Gene expression
Blood
Genes
Modulation
Toxicogenetics
Rat
Untranslated RNA

ASJC Scopus subject areas

  • Education
  • Library and Information Sciences
  • Computer Science Applications
  • Information Systems
  • Statistics, Probability and Uncertainty
  • Statistics and Probability
  • Medicine(all)

Cite this

Minami, K., Uehara, T., Morikawa, Y., Omura, K., Kanki, M., Horinouchi, A., ... Urushidani, T. (2014). MiRNA expression atlas in male rat. Scientific data, 1, [140005]. https://doi.org/10.1038/sdata.2014.5

MiRNA expression atlas in male rat. / Minami, Keiichi; Uehara, Takeki; Morikawa, Yuji; Omura, Ko; Kanki, Masayuki; Horinouchi, Akira; Ono, Atsushi; Yamada, Hiroshi; Ohno, Yasuo; Urushidani, Tetsuro.

In: Scientific data, Vol. 1, 140005, 27.05.2014.

Research output: Contribution to journalArticle

Minami, K, Uehara, T, Morikawa, Y, Omura, K, Kanki, M, Horinouchi, A, Ono, A, Yamada, H, Ohno, Y & Urushidani, T 2014, 'MiRNA expression atlas in male rat', Scientific data, vol. 1, 140005. https://doi.org/10.1038/sdata.2014.5
Minami K, Uehara T, Morikawa Y, Omura K, Kanki M, Horinouchi A et al. MiRNA expression atlas in male rat. Scientific data. 2014 May 27;1. 140005. https://doi.org/10.1038/sdata.2014.5
Minami, Keiichi ; Uehara, Takeki ; Morikawa, Yuji ; Omura, Ko ; Kanki, Masayuki ; Horinouchi, Akira ; Ono, Atsushi ; Yamada, Hiroshi ; Ohno, Yasuo ; Urushidani, Tetsuro. / MiRNA expression atlas in male rat. In: Scientific data. 2014 ; Vol. 1.
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