Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma

Kazushi Nakao, Hitoshi Sugiyama, Eiichi Makino, Hironori Matsuura, Akiko Ohmoto, Taro Sugimoto, Haruo Ichikawa, Jun Wada, Yasushi Yamasaki, Hirofumi Makino

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-β therapy against malignant melanoma. Renal pathologic findings were consistent with minimal change nephrotic syndrome (MCNS) showing extensive foot process effacement of visceral glomerular epithelial cells (podocyte). Nephrotic range proteinuria gradually regressed after stoppage of local injection of IFN-β without glucocorticoid treatment. To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-β therapy for the malignant melanoma.

Original languageEnglish
Pages (from-to)498-500
Number of pages3
JournalNephron
Volume90
Issue number4
DOIs
Publication statusPublished - Apr 25 2002

Keywords

  • Interferon-beta
  • Malignant melanoma
  • Minimal change nephrotic syndrome
  • Proteinuria

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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