Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma

Kazushi Nakao; Hitoshi Sugiyama; Eiichi Makino; Hironori Matsuura; Akiko Ohmoto; Taro Sugimoto; Haruo Ichikawa; Jun Wada; Yasushi Yamasaki; Hirofumi Makino

doi:10.1159/000054740

Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma

Kazushi Nakao, Hitoshi Sugiyama, Eiichi Makino, Hironori Matsuura, Akiko Ohmoto, Taro Sugimoto, Haruo Ichikawa, Jun Wada, Yasushi Yamasaki, Hirofumi Makino

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-β therapy against malignant melanoma. Renal pathologic findings were consistent with minimal change nephrotic syndrome (MCNS) showing extensive foot process effacement of visceral glomerular epithelial cells (podocyte). Nephrotic range proteinuria gradually regressed after stoppage of local injection of IFN-β without glucocorticoid treatment. To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-β therapy for the malignant melanoma.

Original language	English
Pages (from-to)	498-500
Number of pages	3
Journal	Nephron
Volume	90
Issue number	4
DOIs	https://doi.org/10.1159/000054740
Publication status	Published - Apr 25 2002

Keywords

Interferon-beta
Malignant melanoma
Minimal change nephrotic syndrome
Proteinuria

ASJC Scopus subject areas

Physiology
Nephrology
Physiology (medical)
Urology

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10.1159/000054740

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title = "Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma",

abstract = "A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-β therapy against malignant melanoma. Renal pathologic findings were consistent with minimal change nephrotic syndrome (MCNS) showing extensive foot process effacement of visceral glomerular epithelial cells (podocyte). Nephrotic range proteinuria gradually regressed after stoppage of local injection of IFN-β without glucocorticoid treatment. To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-β therapy for the malignant melanoma.",

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T1 - Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma

AU - Nakao, Kazushi

AU - Sugiyama, Hitoshi

AU - Makino, Eiichi

AU - Matsuura, Hironori

AU - Ohmoto, Akiko

AU - Sugimoto, Taro

AU - Ichikawa, Haruo

AU - Wada, Jun

AU - Yamasaki, Yasushi

AU - Makino, Hirofumi

PY - 2002/4/25

Y1 - 2002/4/25

N2 - A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-β therapy against malignant melanoma. Renal pathologic findings were consistent with minimal change nephrotic syndrome (MCNS) showing extensive foot process effacement of visceral glomerular epithelial cells (podocyte). Nephrotic range proteinuria gradually regressed after stoppage of local injection of IFN-β without glucocorticoid treatment. To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-β therapy for the malignant melanoma.

AB - A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-β therapy against malignant melanoma. Renal pathologic findings were consistent with minimal change nephrotic syndrome (MCNS) showing extensive foot process effacement of visceral glomerular epithelial cells (podocyte). Nephrotic range proteinuria gradually regressed after stoppage of local injection of IFN-β without glucocorticoid treatment. To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-β therapy for the malignant melanoma.

KW - Interferon-beta

KW - Malignant melanoma

KW - Minimal change nephrotic syndrome

KW - Proteinuria

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Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma

Abstract

Keywords

ASJC Scopus subject areas

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