Miniaturization and Combinatorial Approach in Organic Electrochemistry

Koichi Mitsudo; Yuji Kurimoto; Kazuki Yoshioka; Seiji Suga

doi:10.1021/acs.chemrev.7b00532

Miniaturization and Combinatorial Approach in Organic Electrochemistry

Koichi Mitsudo, Yuji Kurimoto, Kazuki Yoshioka, Seiji Suga

Research output: Contribution to journal › Review article

24 Citations (Scopus)

Abstract

Recent advances in electro-organic chemistry involving miniaturization, integration, and combinatorial chemistry were reviewed. Microelectrode array technology for site-selective electro-organic reactions and addressable libraries provides a direct and unlabeled method for measuring small-molecule-protein interactions. Electrochemical systems using solid-supported bases and acids ("site separation") can realize electrolysis without the addition of supporting electrolytes. Well-designed "bipolar electrodes" have enabled the production of patterned gradient polymer brushes and microfibers. For the display of combinatorial organic electrochemistry, batch and flow electrolysis systems for the optimization and screening of electro-organic reactions as well as the building of chemical libraries for organic compounds are described.

Original language	English
Pages (from-to)	5985-5999
Number of pages	15
Journal	Chemical Reviews
Volume	118
Issue number	12
DOIs	https://doi.org/10.1021/acs.chemrev.7b00532
Publication status	Published - Jun 27 2018

ASJC Scopus subject areas

Chemistry(all)

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Mitsudo, K., Kurimoto, Y., Yoshioka, K., & Suga, S. (2018). Miniaturization and Combinatorial Approach in Organic Electrochemistry. Chemical Reviews, 118(12), 5985-5999. https://doi.org/10.1021/acs.chemrev.7b00532

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