Millifolides a-c. new 1,10-seco-guaianolides from the flowers of Achillea millefolium

Yong Li, Zhi Yu Ni, Meng Chu Zhu, Kai Zhang, Yi Bing Wu, Mei Dong, Qing Wen Shi, Chang Hong Huo, Françoise Sauriol, Hiromasa Kiyota, Yu Cheng Gu, Bin Cong

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Ten 1,10-secoguaianolides were isolated from the flowers of Achillea millefolium. Their structures were determined on the basis of spectroscopic methods. Three of them (millifolides A-C) including two dimeric sesquiterpenoids exhibit new skeletons. Seco-tanapartholide A exhibited moderate cell growth inhibitory activity against the human cancer cell line MCF7WT (IC50 = 5:51μm) in vitro.

Original languageEnglish
Pages (from-to)438-446
Number of pages9
JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Volume67
Issue number5
DOIs
Publication statusPublished - May 1 2012
Externally publishedYes

Keywords

  • 1,10-Seco-guaianolides
  • Achillea millefolium
  • Cell Growth Inhibition
  • Millifolides A to C
  • Structure Elucidation

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Li, Y., Ni, Z. Y., Zhu, M. C., Zhang, K., Wu, Y. B., Dong, M., Shi, Q. W., Huo, C. H., Sauriol, F., Kiyota, H., Gu, Y. C., & Cong, B. (2012). Millifolides a-c. new 1,10-seco-guaianolides from the flowers of Achillea millefolium. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 67(5), 438-446. https://doi.org/10.5560/ZNB.2012-0028