Millifolides a-c. new 1,10-seco-guaianolides from the flowers of Achillea millefolium

Yong Li, Zhi Yu Ni, Meng Chu Zhu, Kai Zhang, Yi Bing Wu, Mei Dong, Qing Wen Shi, Chang Hong Huo, Françoise Sauriol, Hiromasa Kiyota, Yu Cheng Gu, Bin Cong

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Ten 1,10-secoguaianolides were isolated from the flowers of Achillea millefolium. Their structures were determined on the basis of spectroscopic methods. Three of them (millifolides A-C) including two dimeric sesquiterpenoids exhibit new skeletons. Seco-tanapartholide A exhibited moderate cell growth inhibitory activity against the human cancer cell line MCF7WT (IC50 = 5:51μm) in vitro.

Original languageEnglish
Pages (from-to)438-446
Number of pages9
JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Issue number5
Publication statusPublished - May 2012
Externally publishedYes


  • 1,10-Seco-guaianolides
  • Achillea millefolium
  • Cell Growth Inhibition
  • Millifolides A to C
  • Structure Elucidation

ASJC Scopus subject areas

  • Chemistry(all)


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