Millifolide A, a dimeric ether of degraded sesquiterpene lactones, inhibited the proliferation of human lung cancer cell line A549

Pan Pan Yu, Feng Yu, Wen Zhe Li, Si Ming Wang, Chuan Wang, Mei Dong, Zhi Yu Ni, Yong Li, Hiromasa Kiyota

Research output: Contribution to journalArticlepeer-review

Abstract

The inhibitory effect of three degraded sesquiterpene lactones, iso-seco-tanapartholide, arteludooicinolide A and millifolide A isolated from Achillea millefolium L., on anti-human lung cancer cells was examined using MTT and reporter gene assays. Millifolide A has significant inhibitory effects on the proliferation of human lung cancer cells probably through inducing cell apoptosis.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Achillea millefolium L
  • antiproliferation
  • apoptosis
  • human lung cancer cells
  • millifolide A

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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