Mild and facile deprotection for the synthesis of oligodeoxynucleotide incorporating a 6-O-ethyl-deoxyguanosine

Kohji Seio, Tomoe Negishi, Kazuo Negishi, Mitsuo Sekine

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

The phenoxyacetyl (Pac) group proved to be useful for the synthesis of oligodeoxyribonucleotides incorporating a 6-O-ethylguanine. Since the Pac group could be removed by mild treatment with ammonia, formation of a 2, 4-diaminopurine derivative was avoided. Moreover, the use of the Pac group resulted in significant suppression of the depurination of 6-O-ethyldeoxyguanosine.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalLetters in Organic Chemistry
Volume2
Issue number2
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Deoxyguanosine
Oligodeoxyribonucleotides
Ammonia
Derivatives
6-ethylguanine
O(6)-ethyl-2'-deoxyguanosine

Keywords

  • 6-O-ethylguanine
  • Degenerated base
  • Depurination
  • Mutation
  • Oligodeoxynucleotide synthesis
  • Phenoxyacetyl group

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry

Cite this

Mild and facile deprotection for the synthesis of oligodeoxynucleotide incorporating a 6-O-ethyl-deoxyguanosine. / Seio, Kohji; Negishi, Tomoe; Negishi, Kazuo; Sekine, Mitsuo.

In: Letters in Organic Chemistry, Vol. 2, No. 2, 03.2005, p. 179-183.

Research output: Contribution to journal › Article

Seio, K, Negishi, T, Negishi, K & Sekine, M 2005, 'Mild and facile deprotection for the synthesis of oligodeoxynucleotide incorporating a 6-O-ethyl-deoxyguanosine', Letters in Organic Chemistry, vol. 2, no. 2, pp. 179-183. https://doi.org/10.2174/1570178053202982
Seio K, Negishi T, Negishi K, Sekine M. Mild and facile deprotection for the synthesis of oligodeoxynucleotide incorporating a 6-O-ethyl-deoxyguanosine. Letters in Organic Chemistry. 2005 Mar;2(2):179-183. https://doi.org/10.2174/1570178053202982
Seio, Kohji ; Negishi, Tomoe ; Negishi, Kazuo ; Sekine, Mitsuo. / Mild and facile deprotection for the synthesis of oligodeoxynucleotide incorporating a 6-O-ethyl-deoxyguanosine. In: Letters in Organic Chemistry. 2005 ; Vol. 2, No. 2. pp. 179-183.
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