Abstract
The phenoxyacetyl (Pac) group proved to be useful for the synthesis of oligodeoxyribonucleotides incorporating a 6-O-ethylguanine. Since the Pac group could be removed by mild treatment with ammonia, formation of a 2, 4-diaminopurine derivative was avoided. Moreover, the use of the Pac group resulted in significant suppression of the depurination of 6-O-ethyldeoxyguanosine.
Original language | English |
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Pages (from-to) | 179-183 |
Number of pages | 5 |
Journal | Letters in Organic Chemistry |
Volume | 2 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 1 2005 |
Keywords
- 6-O-ethylguanine
- Degenerated base
- Depurination
- Mutation
- Oligodeoxynucleotide synthesis
- Phenoxyacetyl group
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry