Mild and facile deprotection for the synthesis of oligodeoxynucleotide incorporating a 6-O-ethyl-deoxyguanosine

Kohji Seio, Tomoe Negishi, Kazuo Negishi, Mitsuo Sekine

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The phenoxyacetyl (Pac) group proved to be useful for the synthesis of oligodeoxyribonucleotides incorporating a 6-O-ethylguanine. Since the Pac group could be removed by mild treatment with ammonia, formation of a 2, 4-diaminopurine derivative was avoided. Moreover, the use of the Pac group resulted in significant suppression of the depurination of 6-O-ethyldeoxyguanosine.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalLetters in Organic Chemistry
Volume2
Issue number2
DOIs
Publication statusPublished - Mar 1 2005

Keywords

  • 6-O-ethylguanine
  • Degenerated base
  • Depurination
  • Mutation
  • Oligodeoxynucleotide synthesis
  • Phenoxyacetyl group

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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