TY - JOUR
T1 - Microwave-assisted palladium-catalyzed direct arylation of 1,4-disubstituted 1,2,3-triazoles with aryl chlorides
AU - Iwasaki, Masayuki
AU - Yorimitsu, Hideki
AU - Oshima, Koichiro
PY - 2007/11/15
Y1 - 2007/11/15
N2 - Treatment of 1,4-disubstituted 1,2,3-triazoles with aryl chlorides in the presence of potassium carbonate under palladium catalysis and microwave irradiation at 250°C for 15 min leads to arylation of the triazole at the 5-position. A variety of functional groups, including ester and hydroxy groups, are compatible. The procedure is suitable for the regioselective preparation of trisubstituted triazoles. Microwave irradiation accelerates the reaction, thus allowing the rapid synthesis of trisubstituted triazoles, which are difficult to synthesize selectively.
AB - Treatment of 1,4-disubstituted 1,2,3-triazoles with aryl chlorides in the presence of potassium carbonate under palladium catalysis and microwave irradiation at 250°C for 15 min leads to arylation of the triazole at the 5-position. A variety of functional groups, including ester and hydroxy groups, are compatible. The procedure is suitable for the regioselective preparation of trisubstituted triazoles. Microwave irradiation accelerates the reaction, thus allowing the rapid synthesis of trisubstituted triazoles, which are difficult to synthesize selectively.
KW - Arylation
KW - C-C coupling
KW - Nitrogen beterocycles
KW - Palladium
KW - Triazoles
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U2 - 10.1002/asia.200700206
DO - 10.1002/asia.200700206
M3 - Article
C2 - 17910013
AN - SCOPUS:35948944865
VL - 2
SP - 1430
EP - 1435
JO - Chemistry - An Asian Journal
JF - Chemistry - An Asian Journal
SN - 1861-4728
IS - 11
ER -