Microwave-assisted palladium-catalyzed direct arylation of 1,4-disubstituted 1,2,3-triazoles with aryl chlorides

Masayuki Iwasaki, Hideki Yorimitsu, Koichiro Oshima

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Treatment of 1,4-disubstituted 1,2,3-triazoles with aryl chlorides in the presence of potassium carbonate under palladium catalysis and microwave irradiation at 250°C for 15 min leads to arylation of the triazole at the 5-position. A variety of functional groups, including ester and hydroxy groups, are compatible. The procedure is suitable for the regioselective preparation of trisubstituted triazoles. Microwave irradiation accelerates the reaction, thus allowing the rapid synthesis of trisubstituted triazoles, which are difficult to synthesize selectively.

Original languageEnglish
Pages (from-to)1430-1435
Number of pages6
JournalChemistry - An Asian Journal
Volume2
Issue number11
DOIs
Publication statusPublished - 2007
Externally publishedYes

Fingerprint

Triazoles
Palladium
Microwaves
Chlorides
Microwave irradiation
Catalysis
Functional groups
Esters

Keywords

  • Arylation
  • C-C coupling
  • Nitrogen beterocycles
  • Palladium
  • Triazoles

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Microwave-assisted palladium-catalyzed direct arylation of 1,4-disubstituted 1,2,3-triazoles with aryl chlorides. / Iwasaki, Masayuki; Yorimitsu, Hideki; Oshima, Koichiro.

In: Chemistry - An Asian Journal, Vol. 2, No. 11, 2007, p. 1430-1435.

Research output: Contribution to journalArticle

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