Microwave-assisted palladium-catalyzed allylation of aryl halides with homoallyl alcohols via retro-allylation

Masayuki Iwasaki, Sayuri Hayashi, Koji Hirano, Hideki Yorimitsu, Koichiro Oshima

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The palladium-catalyzed allylation of aryl halides with homoallyl alcohols via retro-allylation proceeds at 200-250 °C in a toluene-DMF mixed solvent using microwave heating. Even at such high temperatures, the regio- and stereospecificity of the allyl transfer reaction is still satisfactory. The amount of the palladium catalyst can be reduced to 0.5 or 0.05 mol %.

Original languageEnglish
Pages (from-to)5200-5203
Number of pages4
JournalTetrahedron
Volume63
Issue number24
DOIs
Publication statusPublished - Jun 11 2007
Externally publishedYes

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Keywords

  • Allylation
  • Carbon-carbon bond cleavage
  • Microwaves
  • Palladium

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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