Microstructure evolution in Stöber-type silica nanoparticles and their in vitro apatite deposition

Song Chen, Akiyoshi Osaka, Satoshi Hayakawa, Kanji Tsuru, Eiji Fujii, Koji Kawabata

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Prepared via Stöber-type sol-gel routes were three types of silica particles of 2-containing ethanol/water solutions. Scanning and transmission electron micrograph analyses indicated that those silica particles consisted of ~10 nm primary particles, the Ca-silica particles (~500 nm) were larger than the Ca-free ones (~200 nm) and that their size increased with the Ca concentration in the precursor solutions. From 1H- and 29Si- magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectra and 29Si cross-polarization NMR spectra, the mechanism of primary particle agglomeration and degradation of the secondary particles in saline were discussed in terms of the content of H2O molecules and >Si-OH as well as hydrogen bonding interactions among them. In addition, the Ca-silica and core-shell silica deposited apatite in Kokubo's simulated body fluid. Thus, the present Ca-silica and polymer-coated silica particles were suggested to be applicable to injectable bone fillers for bone generation.

Original languageEnglish
Pages (from-to)322-335
Number of pages14
JournalJournal of Sol-Gel Science and Technology
Volume48
Issue number3
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Apatites
Apatite
apatites
Silicon Dioxide
Silica
Nanoparticles
silicon dioxide
nanoparticles
microstructure
Microstructure
bones
Bone
Nuclear magnetic resonance
nuclear magnetic resonance
Magic angle spinning
body fluids
Body fluids
cross polarization
agglomeration
fillers

Keywords

  • H and Si MAS NMR
  • Si CP-MAS NMR
  • Apatite
  • Degradation
  • Microstructure
  • Particles
  • Polymer-coating
  • SBF
  • Silica

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Biomaterials
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry

Cite this

Microstructure evolution in Stöber-type silica nanoparticles and their in vitro apatite deposition. / Chen, Song; Osaka, Akiyoshi; Hayakawa, Satoshi; Tsuru, Kanji; Fujii, Eiji; Kawabata, Koji.

In: Journal of Sol-Gel Science and Technology, Vol. 48, No. 3, 12.2008, p. 322-335.

Research output: Contribution to journalArticle

Chen, Song ; Osaka, Akiyoshi ; Hayakawa, Satoshi ; Tsuru, Kanji ; Fujii, Eiji ; Kawabata, Koji. / Microstructure evolution in Stöber-type silica nanoparticles and their in vitro apatite deposition. In: Journal of Sol-Gel Science and Technology. 2008 ; Vol. 48, No. 3. pp. 322-335.
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