MicroRNAs in soft tissue sarcomas: Overview of the accumulating evidence and importance as novel biomarkers

Tomohiro Fujiwara, Toshiyuki Kunisada, Ken Takeda, Koji Uotani, Aki Yoshida, Takahiro Ochiya, Toshihumi Ozaki

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Sarcomas are distinctly heterogeneous tumors and a variety of subtypes have been described. Although several diagnostic explorations in the past three decades, such as identification of chromosomal translocation, have greatly improved the diagnosis of soft tissue sarcomas, the unsolved issues, including the limited useful biomarkers, remain. Emerging reports on miRNAs in soft tissue sarcomas have provided clues to solving these problems. Evidence of circulating miRNAs in patients with soft tissue sarcomas and healthy individuals has been accumulated and is accelerating their potential to develop into clinical applications. Moreover, miRNAs that function as novel prognostic factors have been identified, thereby facilitating their use in miRNA-targeted therapy. In this review, we provide an overview of the current knowledge on miRNA deregulation in soft tissue sarcomas, and discuss their potential as novel biomarkers and therapeutics.

Original languageEnglish
Article number592868
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Biomarkers
MicroRNAs
Sarcoma
Tissue
Genetic Translocation
Deregulation
Tumors
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

MicroRNAs in soft tissue sarcomas : Overview of the accumulating evidence and importance as novel biomarkers. / Fujiwara, Tomohiro; Kunisada, Toshiyuki; Takeda, Ken; Uotani, Koji; Yoshida, Aki; Ochiya, Takahiro; Ozaki, Toshihumi.

In: BioMed Research International, Vol. 2014, 592868, 2014.

Research output: Contribution to journalArticle

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