MicroRNAs as biomarkers for nephrotic syndrome

Research output: Contribution to journalReview articlepeer-review

Abstract

Nephrotic syndrome represents the clinical situation characterized by presence of massive proteinuria and low serum protein caused by a variety of diseases, including minimal change ne-phrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS) and membranous glomeru-lonephropathy. Differentiating between diagnoses requires invasive renal biopsies in general. Even with the biopsy, we encounter difficulties to differentiate MCNS and FSGS in some cases. There is no other better option currently available for the diagnosis other than renal biopsy. MicroRNAs (miRNAs) are no-coding RNAs of approximately 20 nucleotides in length, which regulate target genes in the post-transcriptional processes and have essential roles in many diseases. MiRNAs in serum and urine have been shown as non-invasive biomarkers in multiple diseases, including renal diseases. In this article, we summarize the current knowledge of miRNAs as the promising bi-omarkers for nephrotic syndrome.

Original languageEnglish
Article number88
Pages (from-to)1-15
Number of pages15
JournalInternational journal of molecular sciences
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2021

Keywords

  • Biomarker
  • Focal segmental glomerulosclerosis
  • Membranous glomerulonephropathy
  • MicroRNA
  • Minimal change nephrotic syndrome
  • Nephrotic syndrome

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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