Abstract
This conference proceeding reports a preliminary result regarding a simple technique to fabricate core-shell tetra-arm poly(ethylene glycol) (tetra-PEG) hydrogel microbeads encapsulating insulin-secreting cells using microfluidic emulsification and interfacial coupling reaction of two kinds of tetra-PEG macromonomers at the core-shell interface in the precursor aqueous droplets. Different from conventional PEG-based microbeads formation, in situ gelation system utilizing self-diffusion of the macromonomers in confined microdroplets allowed to prepare tetra-PEG hydrogel microbeads with narrow size distribution under mild gelation condition in the absence of heating and UV irradiation. This technology can be used to generate monodisperse tetra-PEG hydrogel microbeads to encapsulate sensitive cells for regenerative medicines.
| Original language | English |
|---|---|
| Title of host publication | MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 718-720 |
| Number of pages | 3 |
| Volume | 2016-February |
| ISBN (Electronic) | 9781509019731 |
| DOIs | |
| Publication status | Published - Feb 26 2016 |
| Externally published | Yes |
| Event | 29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016 - Shanghai, China Duration: Jan 24 2016 → Jan 28 2016 |
Other
| Other | 29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016 |
|---|---|
| Country | China |
| City | Shanghai |
| Period | 1/24/16 → 1/28/16 |
Fingerprint
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Mechanical Engineering
- Condensed Matter Physics
- Electronic, Optical and Magnetic Materials
Cite this
Microfluidic formation of monodisperse tetra-PEG hydrogel microbeads for cell encapsulation. / Watanabe, Takaichi; Takeuchi, Shoji.
MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems. Vol. 2016-February Institute of Electrical and Electronics Engineers Inc., 2016. p. 718-720 7421728.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Microfluidic formation of monodisperse tetra-PEG hydrogel microbeads for cell encapsulation
AU - Watanabe, Takaichi
AU - Takeuchi, Shoji
PY - 2016/2/26
Y1 - 2016/2/26
N2 - This conference proceeding reports a preliminary result regarding a simple technique to fabricate core-shell tetra-arm poly(ethylene glycol) (tetra-PEG) hydrogel microbeads encapsulating insulin-secreting cells using microfluidic emulsification and interfacial coupling reaction of two kinds of tetra-PEG macromonomers at the core-shell interface in the precursor aqueous droplets. Different from conventional PEG-based microbeads formation, in situ gelation system utilizing self-diffusion of the macromonomers in confined microdroplets allowed to prepare tetra-PEG hydrogel microbeads with narrow size distribution under mild gelation condition in the absence of heating and UV irradiation. This technology can be used to generate monodisperse tetra-PEG hydrogel microbeads to encapsulate sensitive cells for regenerative medicines.
AB - This conference proceeding reports a preliminary result regarding a simple technique to fabricate core-shell tetra-arm poly(ethylene glycol) (tetra-PEG) hydrogel microbeads encapsulating insulin-secreting cells using microfluidic emulsification and interfacial coupling reaction of two kinds of tetra-PEG macromonomers at the core-shell interface in the precursor aqueous droplets. Different from conventional PEG-based microbeads formation, in situ gelation system utilizing self-diffusion of the macromonomers in confined microdroplets allowed to prepare tetra-PEG hydrogel microbeads with narrow size distribution under mild gelation condition in the absence of heating and UV irradiation. This technology can be used to generate monodisperse tetra-PEG hydrogel microbeads to encapsulate sensitive cells for regenerative medicines.
UR - http://www.scopus.com/inward/record.url?scp=84970974371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84970974371&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2016.7421728
DO - 10.1109/MEMSYS.2016.7421728
M3 - Conference contribution
VL - 2016-February
SP - 718
EP - 720
BT - MEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems
PB - Institute of Electrical and Electronics Engineers Inc.
ER -