Microfluidic extraction of docosahexaenoic acid ethyl ester: Comparison between slug flow and emulsion

Eiji Kamio, Yu Seike, Hidekazu Yoshizawa, Hideto Matsuyama, Tsutomu Ono

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Microfluidic liquid-liquid extraction of the ethyl ester of docosahexaenoic acid (DHA-Et) with silver ions was investigated using slug flow and a water-in-oil (W/O) emulsion as specific flow patterns possessing large interfacial areas. To compare the extraction rates of both systems, slug flow and a W/O emulsion with similar specific interfacial areas were prepared. Extraction rates for the systems were the same at 298 K. However, at 268 K, slug flow had a faster extraction rate than the W/O emulsion. Theoretical calculation follows the results for both systems at 298 K and for the slug flow system at 268 K, suggesting that the emulsion stabilizer inhibits complex formation between DHA-Et and silver ions at the O/W interface. A reduction in extraction rate was observed in the slug flow system at 268 K when the emulsion stabilizer was used. Slug flow can be prepared without stabilizer, offering advantages over emulsions in microfluidic extraction.

Original languageEnglish
Pages (from-to)6915-6924
Number of pages10
JournalIndustrial and Engineering Chemistry Research
Volume50
Issue number11
DOIs
Publication statusPublished - Jun 1 2011

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Emulsions
Microfluidics
Esters
Acids
Oils
Silver
Water
Ions
Liquids
Flow patterns
4,7,10,13,16,19-docosahexaenoic acid ethyl ester

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Industrial and Manufacturing Engineering

Cite this

Microfluidic extraction of docosahexaenoic acid ethyl ester : Comparison between slug flow and emulsion. / Kamio, Eiji; Seike, Yu; Yoshizawa, Hidekazu; Matsuyama, Hideto; Ono, Tsutomu.

In: Industrial and Engineering Chemistry Research, Vol. 50, No. 11, 01.06.2011, p. 6915-6924.

Research output: Contribution to journalArticle

Kamio, Eiji ; Seike, Yu ; Yoshizawa, Hidekazu ; Matsuyama, Hideto ; Ono, Tsutomu. / Microfluidic extraction of docosahexaenoic acid ethyl ester : Comparison between slug flow and emulsion. In: Industrial and Engineering Chemistry Research. 2011 ; Vol. 50, No. 11. pp. 6915-6924.
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