Microfluidic extraction of docosahexaenoic acid ethyl ester: Comparison between slug flow and emulsion

Eiji Kamio; Yu Seike; Hidekazu Yoshizawa; Hideto Matsuyama; Tsutomu Ono

doi:10.1021/ie102207c

Microfluidic extraction of docosahexaenoic acid ethyl ester: Comparison between slug flow and emulsion

Eiji Kamio, Yu Seike, Hidekazu Yoshizawa, Hideto Matsuyama, Tsutomu Ono

Research output: Contribution to journal › Article

21 Citations (Scopus)

Abstract

Microfluidic liquid-liquid extraction of the ethyl ester of docosahexaenoic acid (DHA-Et) with silver ions was investigated using slug flow and a water-in-oil (W/O) emulsion as specific flow patterns possessing large interfacial areas. To compare the extraction rates of both systems, slug flow and a W/O emulsion with similar specific interfacial areas were prepared. Extraction rates for the systems were the same at 298 K. However, at 268 K, slug flow had a faster extraction rate than the W/O emulsion. Theoretical calculation follows the results for both systems at 298 K and for the slug flow system at 268 K, suggesting that the emulsion stabilizer inhibits complex formation between DHA-Et and silver ions at the O/W interface. A reduction in extraction rate was observed in the slug flow system at 268 K when the emulsion stabilizer was used. Slug flow can be prepared without stabilizer, offering advantages over emulsions in microfluidic extraction.

Original language	English
Pages (from-to)	6915-6924
Number of pages	10
Journal	Industrial and Engineering Chemistry Research
Volume	50
Issue number	11
DOIs	https://doi.org/10.1021/ie102207c
Publication status	Published - Jun 1 2011

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)
Industrial and Manufacturing Engineering

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Kamio, E., Seike, Y., Yoshizawa, H., Matsuyama, H., & Ono, T. (2011). Microfluidic extraction of docosahexaenoic acid ethyl ester: Comparison between slug flow and emulsion. Industrial and Engineering Chemistry Research, 50(11), 6915-6924. https://doi.org/10.1021/ie102207c

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abstract = "Microfluidic liquid-liquid extraction of the ethyl ester of docosahexaenoic acid (DHA-Et) with silver ions was investigated using slug flow and a water-in-oil (W/O) emulsion as specific flow patterns possessing large interfacial areas. To compare the extraction rates of both systems, slug flow and a W/O emulsion with similar specific interfacial areas were prepared. Extraction rates for the systems were the same at 298 K. However, at 268 K, slug flow had a faster extraction rate than the W/O emulsion. Theoretical calculation follows the results for both systems at 298 K and for the slug flow system at 268 K, suggesting that the emulsion stabilizer inhibits complex formation between DHA-Et and silver ions at the O/W interface. A reduction in extraction rate was observed in the slug flow system at 268 K when the emulsion stabilizer was used. Slug flow can be prepared without stabilizer, offering advantages over emulsions in microfluidic extraction.",

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