Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.

Panarat Arunrattiyakorn, Sunit Suksamrarn, Nuttika Suwannasai, Hiroshi Kanzaki

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

α-Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively. Incubation of 1 with C. gloeosporioides (EYL131) gave four metabolites which were identified as mangostin 3-sulfate (2), mangostanin 6-sulfate (3), 17,18-dihydroxymangostanin 6-sulfate (4)and isomangostanin 3-sulfate (5). Compound 2 was also formed by incubation with N. spathulata (EYR042). The structures of the isolated compounds were elucidated by spectroscopic data analysis. Of the isolated metabolites, 2 exhibited significant anti-mycobacterial activity against Mycobacterium tuberculosis.

Original languageEnglish
Pages (from-to)730-734
Number of pages5
JournalPhytochemistry
Volume72
Issue number8
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Garcinia mangostana
Garcinia
Metabolism
Sulfates
sulfates
metabolism
Glomerella cingulata
Metabolites
Neosartorya
Colletotrichum
metabolites
xanthone
Mycobacterium tuberculosis
Fruits
Fungi
hulls
Fruit
data analysis
fungi
fruits

Keywords

  • α-Mangostin
  • Anti-mycobacterial activity
  • Microbial metabolism
  • Sulfation

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Horticulture

Cite this

Arunrattiyakorn, P., Suksamrarn, S., Suwannasai, N., & Kanzaki, H. (2011). Microbial metabolism of α-mangostin isolated from Garcinia mangostana L. Phytochemistry, 72(8), 730-734. https://doi.org/10.1016/j.phytochem.2011.02.007

Microbial metabolism of α-mangostin isolated from Garcinia mangostana L. / Arunrattiyakorn, Panarat; Suksamrarn, Sunit; Suwannasai, Nuttika; Kanzaki, Hiroshi.

In: Phytochemistry, Vol. 72, No. 8, 06.2011, p. 730-734.

Research output: Contribution to journalArticle

Arunrattiyakorn, P, Suksamrarn, S, Suwannasai, N & Kanzaki, H 2011, 'Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.', Phytochemistry, vol. 72, no. 8, pp. 730-734. https://doi.org/10.1016/j.phytochem.2011.02.007
Arunrattiyakorn, Panarat ; Suksamrarn, Sunit ; Suwannasai, Nuttika ; Kanzaki, Hiroshi. / Microbial metabolism of α-mangostin isolated from Garcinia mangostana L. In: Phytochemistry. 2011 ; Vol. 72, No. 8. pp. 730-734.
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