Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.

Panarat Arunrattiyakorn, Sunit Suksamrarn, Nuttika Suwannasai, Hiroshi Kanzaki

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

α-Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively. Incubation of 1 with C. gloeosporioides (EYL131) gave four metabolites which were identified as mangostin 3-sulfate (2), mangostanin 6-sulfate (3), 17,18-dihydroxymangostanin 6-sulfate (4)and isomangostanin 3-sulfate (5). Compound 2 was also formed by incubation with N. spathulata (EYR042). The structures of the isolated compounds were elucidated by spectroscopic data analysis. Of the isolated metabolites, 2 exhibited significant anti-mycobacterial activity against Mycobacterium tuberculosis.

Original languageEnglish
Pages (from-to)730-734
Number of pages5
JournalPhytochemistry
Volume72
Issue number8
DOIs
Publication statusPublished - Jun 1 2011

Keywords

  • Anti-mycobacterial activity
  • Microbial metabolism
  • Sulfation
  • α-Mangostin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Fingerprint Dive into the research topics of 'Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.'. Together they form a unique fingerprint.

  • Cite this

    Arunrattiyakorn, P., Suksamrarn, S., Suwannasai, N., & Kanzaki, H. (2011). Microbial metabolism of α-mangostin isolated from Garcinia mangostana L. Phytochemistry, 72(8), 730-734. https://doi.org/10.1016/j.phytochem.2011.02.007