Microbial hydrolysis of diketopiperazines: Different types of diketopiperazine-assimilating bacteria

Hiroshi Kanzaki, Shuji Oda, Akio Kobayashi, Kazuyoshi Kawazu

Research output: Contribution to journalArticle

3 Citations (Scopus)


Arthrobacter sp. 1-3-1 and a coryneform rod bacterium, strain T-1-3-Y, which assimilate cyclo(Gly-Gly) and cyclo(Gly-L-Tyr) at high rates, respectively, were isolated from soil. Both bacteria exhibit diketopiperazine-hydrolyzing activity intracellularly in contrast to the extracellular cyclo(Gly-Gly) hydrolase reported previously. Arthrobacter sp. 1-3-1 shows a much broader substrate specificity than strain T-1-3-Y, indicating the diversity of diketopiperazine hydrolysis in nature.

Original languageEnglish
Pages (from-to)386-388
Number of pages3
JournalJournal of Fermentation and Bioengineering
Issue number4
Publication statusPublished - Jan 1 1997



  • Cyclo(Gly-Gly)
  • Cyclo(Gly-L-Tyr)
  • Enrichment culture
  • Glycine anhydride

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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