Mice lacking NK cells develop an efficient Th1 response and control cutaneous Leishmania major infection

Abhay R. Satoskar, Luisa M. Stamm, Xingmin Zhang, Anjali A. Satoskar, Mitsuhiro Okano, Cox Terhorst, John R. David, Baoping Wang

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Abstract

NK cells are believed to play a critical role in the development of immunity against Leishmania major. We recently found that transplantation of wild-type bone marrow cells into neonatal tgε 26 mice, which are deficient in T and NK cells, resulted in normal T cell development, but no or poor NK cell development. Using this novel model we analyzed the role of NK cells in the development of Th1 response and control of cutaneous L. major infection. Mice selectively lacking NK cells (NK-T+) developed an efficient Th1-like response, produced significant amounts of IL-12 and IFN-γ, and controlled cutaneous L. major infection. Administration of neutralizing IL-12 Abs to NK-T+ mice during L. major infection resulted in exacerbation of the disease. These results demonstrate that NK cells are not critical for development of protective immunity against L. major. Furthermore, they indicate that IL-12 can induce development of Th1 response independent of NK cells in NK-T+ mice following L. major infection.

Original languageEnglish
Pages (from-to)6747-6754
Number of pages8
JournalJournal of Immunology
Volume162
Issue number11
Publication statusPublished - Jun 1 1999

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Satoskar, A. R., Stamm, L. M., Zhang, X., Satoskar, A. A., Okano, M., Terhorst, C., David, J. R., & Wang, B. (1999). Mice lacking NK cells develop an efficient Th1 response and control cutaneous Leishmania major infection. Journal of Immunology, 162(11), 6747-6754.