MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness

Michael Lahn, Arihiko Kanehiro, Katsuyuki Takeda, Jennifer Terry, Youn Soo Hahn, M. Kemal Aydintug, Anatole Konowal, Koichi Ikuta, Rebecca L. O'Brien, Erwin W. Gelfand, Willi K. Born

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69 Citations (Scopus)


Mice exposed to aerosolized ovalbumin (OVA) develop increased airway responsiveness when deficient in γδ T cells. This finding suggests that γδ T cells function as negative regulators. The regulatory influence of γδ T cells is evident after OVA-sensitization and -challenge, and after OVA-challenge alone, but not in untreated mice. With aerosolized Abs to target pulmonary T cells, we now demonstrate that negative regulation of airway responsiveness is mediated by a small subpopulation of pulmonary γδ T cells. These cells express Vγ4 and depend in their function on the presence of IFN-γ and MHC class I. Moreover, their effect can be demonstrated in the absence of αβ T cells. This novel type of negative regulation seems to precede the development of the adaptive, antigen-specific allergic response.

Original languageEnglish
Pages (from-to)8850-8855
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number13
Publication statusPublished - Jun 25 2002
Externally publishedYes

ASJC Scopus subject areas

  • General


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