MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness

Michael Lahn, Arihiko Kanehiro, Katsuyuki Takeda, Jennifer Terry, Youn Soo Hahn, M. Kemal Aydintug, Anatole Konowal, Koichi Ikuta, Rebecca L. O'Brien, Erwin W. Gelfand, Willi K. Born

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Mice exposed to aerosolized ovalbumin (OVA) develop increased airway responsiveness when deficient in γδ T cells. This finding suggests that γδ T cells function as negative regulators. The regulatory influence of γδ T cells is evident after OVA-sensitization and -challenge, and after OVA-challenge alone, but not in untreated mice. With aerosolized Abs to target pulmonary T cells, we now demonstrate that negative regulation of airway responsiveness is mediated by a small subpopulation of pulmonary γδ T cells. These cells express Vγ4 and depend in their function on the presence of IFN-γ and MHC class I. Moreover, their effect can be demonstrated in the absence of αβ T cells. This novel type of negative regulation seems to precede the development of the adaptive, antigen-specific allergic response.

Original languageEnglish
Pages (from-to)8850-8855
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number13
DOIs
Publication statusPublished - Jun 25 2002
Externally publishedYes

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T-Lymphocytes
Ovalbumin
Lung
Regulatory T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness. / Lahn, Michael; Kanehiro, Arihiko; Takeda, Katsuyuki; Terry, Jennifer; Hahn, Youn Soo; Aydintug, M. Kemal; Konowal, Anatole; Ikuta, Koichi; O'Brien, Rebecca L.; Gelfand, Erwin W.; Born, Willi K.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 13, 25.06.2002, p. 8850-8855.

Research output: Contribution to journalArticle

Lahn, M, Kanehiro, A, Takeda, K, Terry, J, Hahn, YS, Aydintug, MK, Konowal, A, Ikuta, K, O'Brien, RL, Gelfand, EW & Born, WK 2002, 'MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 13, pp. 8850-8855. https://doi.org/10.1073/pnas.132519299
Lahn, Michael ; Kanehiro, Arihiko ; Takeda, Katsuyuki ; Terry, Jennifer ; Hahn, Youn Soo ; Aydintug, M. Kemal ; Konowal, Anatole ; Ikuta, Koichi ; O'Brien, Rebecca L. ; Gelfand, Erwin W. ; Born, Willi K. / MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness. In: Proceedings of the National Academy of Sciences of the United States of America. 2002 ; Vol. 99, No. 13. pp. 8850-8855.
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