MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness

Michael Lahn, Arihiko Kanehiro, Katsuyuki Takeda, Jennifer Terry, Youn Soo Hahn, M. Kemal Aydintug, Anatole Konowal, Koichi Ikuta, Rebecca L. O'Brien, Erwin W. Gelfand, Willi K. Born

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Abstract

Mice exposed to aerosolized ovalbumin (OVA) develop increased airway responsiveness when deficient in γδ T cells. This finding suggests that γδ T cells function as negative regulators. The regulatory influence of γδ T cells is evident after OVA-sensitization and -challenge, and after OVA-challenge alone, but not in untreated mice. With aerosolized Abs to target pulmonary T cells, we now demonstrate that negative regulation of airway responsiveness is mediated by a small subpopulation of pulmonary γδ T cells. These cells express Vγ4 and depend in their function on the presence of IFN-γ and MHC class I. Moreover, their effect can be demonstrated in the absence of αβ T cells. This novel type of negative regulation seems to precede the development of the adaptive, antigen-specific allergic response.

Original languageEnglish
Pages (from-to)8850-8855
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number13
DOIs
Publication statusPublished - Jun 25 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Lahn, M., Kanehiro, A., Takeda, K., Terry, J., Hahn, Y. S., Aydintug, M. K., Konowal, A., Ikuta, K., O'Brien, R. L., Gelfand, E. W., & Born, W. K. (2002). MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness. Proceedings of the National Academy of Sciences of the United States of America, 99(13), 8850-8855. https://doi.org/10.1073/pnas.132519299