Methylenetetrahydrofolate reductase [correction of reducatase] polymorphism and asthma

Chao chun Zou, Lan fang Tang, Mi zu Jiang, Zheng yan Zhao, Tsukahara Hirokazu, Mayumi Mitsufumi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma. METHOD: Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47). CONCLUSION: These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalZhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Volume26
Issue number3
Publication statusPublished - Mar 2003
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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