Abstract
OBJECTIVE: To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma. METHOD: Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47). CONCLUSION: These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.
Original language | English |
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Pages (from-to) | 161-164 |
Number of pages | 4 |
Journal | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases |
Volume | 26 |
Issue number | 3 |
Publication status | Published - Mar 2003 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)