Methylenetetrahydrofolate reductase [correction of reducatase] polymorphism and asthma

Chao chun Zou; Lan fang Tang; Mi zu Jiang; Zheng yan Zhao; Tsukahara Hirokazu; Mayumi Mitsufumi

Methylenetetrahydrofolate reductase [correction of reducatase] polymorphism and asthma

Chao chun Zou, Lan fang Tang, Mi zu Jiang, Zheng yan Zhao, Tsukahara Hirokazu, Mayumi Mitsufumi

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma. METHOD: Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47). CONCLUSION: These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.

Original language	English
Pages (from-to)	161-164
Number of pages	4
Journal	Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Volume	26
Issue number	3
Publication status	Published - Mar 2003
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Methylenetetrahydrofolate reductase [correction of reducatase] polymorphism and asthma. / Zou, Chao chun; Tang, Lan fang; Jiang, Mi zu; Zhao, Zheng yan; Hirokazu, Tsukahara; Mitsufumi, Mayumi.

In: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, Vol. 26, No. 3, 03.2003, p. 161-164.

Research output: Contribution to journal › Article › peer-review

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abstract = "OBJECTIVE: To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma. METHOD: Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47). CONCLUSION: These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.",

author = "Zou, {Chao chun} and Tang, {Lan fang} and Jiang, {Mi zu} and Zhao, {Zheng yan} and Tsukahara Hirokazu and Mayumi Mitsufumi",

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AU - Zou, Chao chun

AU - Tang, Lan fang

AU - Jiang, Mi zu

AU - Zhao, Zheng yan

AU - Hirokazu, Tsukahara

AU - Mitsufumi, Mayumi

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N2 - OBJECTIVE: To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma. METHOD: Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47). CONCLUSION: These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.

AB - OBJECTIVE: To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma. METHOD: Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47). CONCLUSION: These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.

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