Abstract
OBJECTIVE: To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma. METHOD: Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47). CONCLUSION: These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 161-164 |
| Number of pages | 4 |
| Journal | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases |
| Volume | 26 |
| Issue number | 3 |
| Publication status | Published - Mar 2003 |
| Externally published | Yes |
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Methylenetetrahydrofolate reductase [correction of reducatase] polymorphism and asthma. / Zou, Chao chun; Tang, Lan fang; Jiang, Mi zu; Zhao, Zheng yan; Tsukahara, Hirokazu; Mitsufumi, Mayumi.
In: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, Vol. 26, No. 3, 03.2003, p. 161-164.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Methylenetetrahydrofolate reductase [correction of reducatase] polymorphism and asthma
AU - Zou, Chao chun
AU - Tang, Lan fang
AU - Jiang, Mi zu
AU - Zhao, Zheng yan
AU - Tsukahara, Hirokazu
AU - Mitsufumi, Mayumi
PY - 2003/3
Y1 - 2003/3
N2 - OBJECTIVE: To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma. METHOD: Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47). CONCLUSION: These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.
AB - OBJECTIVE: To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma. METHOD: Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47). CONCLUSION: These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.
UR - http://www.scopus.com/inward/record.url?scp=21244449621&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21244449621&partnerID=8YFLogxK
M3 - Article
C2 - 12816682
AN - SCOPUS:21244449621
VL - 26
SP - 161
EP - 164
JO - Zhonghua jie he he hu xi xi ji bing za zhi = Chinese journal of tuberculosis and respiratory diseases
JF - Zhonghua jie he he hu xi xi ji bing za zhi = Chinese journal of tuberculosis and respiratory diseases
SN - 1001-0939
IS - 3
ER -