Methoxylation of Acyl Fluorides with Tris(2,4,6-trimethoxyphenyl)phosphine via C-OMe Bond Cleavage under Metal-Free Conditions

Xiu Wang, Zhenhua Wang, Takumi Ishida, Yasushi Nishihara

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Acyl fluorides are subjected to methoxylation with tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) to afford the corresponding methyl esters in good to excellent yields. This transformation is featured by C(sp2)-OMe bond cleavage under metal-free conditions. Unprecedented utilization of TMPP as a methoxylating agent realized the installation of an OMe group into the desired products.

    Original languageEnglish
    Pages (from-to)7526-7533
    Number of pages8
    JournalJournal of Organic Chemistry
    Volume85
    Issue number11
    DOIs
    Publication statusPublished - Jun 5 2020

    ASJC Scopus subject areas

    • Organic Chemistry

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