Methoxylation of Acyl Fluorides with Tris(2,4,6-trimethoxyphenyl)phosphine via C-OMe Bond Cleavage under Metal-Free Conditions

Xiu Wang, Zhenhua Wang, Takumi Ishida, Yasushi Nishihara

Research output: Contribution to journalArticle

Abstract

Acyl fluorides are subjected to methoxylation with tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) to afford the corresponding methyl esters in good to excellent yields. This transformation is featured by C(sp2)-OMe bond cleavage under metal-free conditions. Unprecedented utilization of TMPP as a methoxylating agent realized the installation of an OMe group into the desired products.

Original languageEnglish
Pages (from-to)7526-7533
Number of pages8
JournalJournal of Organic Chemistry
Volume85
Issue number11
DOIs
Publication statusPublished - Jun 5 2020

ASJC Scopus subject areas

  • Organic Chemistry

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