TY - JOUR
T1 - Methoxylation of Acyl Fluorides with Tris(2,4,6-trimethoxyphenyl)phosphine via C-OMe Bond Cleavage under Metal-Free Conditions
AU - Wang, Xiu
AU - Wang, Zhenhua
AU - Ishida, Takumi
AU - Nishihara, Yasushi
N1 - Funding Information:
This study was partly supported by the Marubun Research Promotion Foundation. We gratefully thank the SC-NMR Laboratory (Okayama University) for the NMR spectral measurements.
Publisher Copyright:
Copyright © 2020 American Chemical Society.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/5
Y1 - 2020/6/5
N2 - Acyl fluorides are subjected to methoxylation with tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) to afford the corresponding methyl esters in good to excellent yields. This transformation is featured by C(sp2)-OMe bond cleavage under metal-free conditions. Unprecedented utilization of TMPP as a methoxylating agent realized the installation of an OMe group into the desired products.
AB - Acyl fluorides are subjected to methoxylation with tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) to afford the corresponding methyl esters in good to excellent yields. This transformation is featured by C(sp2)-OMe bond cleavage under metal-free conditions. Unprecedented utilization of TMPP as a methoxylating agent realized the installation of an OMe group into the desired products.
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U2 - 10.1021/acs.joc.0c00640
DO - 10.1021/acs.joc.0c00640
M3 - Article
AN - SCOPUS:85086673952
SN - 0022-3263
VL - 85
SP - 7526
EP - 7533
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 11
ER -