Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy

Seiichiro Makihara, Shin Kariya, Mai Noujima-Harada, Nobuya Ohara, Tomoyuki Naito, Junya Matsumoto, Yohei Noda, Mitsuhiro Okano, Tadashi Yoshino, Kazunori Nishizaki

Research output: Contribution to journalArticle

Abstract

As has been well recognized, methotrexate (MTX) leads to a state of immunosuppression and can provide a basis for the development of lymphoproliferative disorders (LPDs). MTX-associated LPDs can affect nodal sites as well as extranodal sites, though the manifestation of an LPD in the form of multiple pulmonary nodules is rare. Here, we report two cases of MTX-associated LPD with multiple bilateral pulmonary nodules, which was a finding suggestive of lung cancer, and bilateral cervical lymphadenopathy. After withdrawal of MTX, the multiple bilateral pulmonary nodules and bilateral cervical lymphadenopathy disappeared without chemotherapy in both cases. From these results, patients with pulmonary nodules and cervical lymphadenopathy should be examined for head and neck malignant tumors. Also, physicians should carefully check the administration of MTX. In patients with an MTX-associated LPD, we need to make an early diagnosis and consider discontinuing the administration of MTX as soon as possible.

Original languageEnglish
JournalAuris Nasus Larynx
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Multiple Pulmonary Nodules
Lymphoproliferative Disorders
Methotrexate
Lymphadenopathy
Immunosuppression
Early Diagnosis
Lung Neoplasms
Neck
Head
Physicians
Drug Therapy
Lung

Keywords

  • Methotrexate
  • MTX-associated LPD
  • Pulmonary nodules

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy. / Makihara, Seiichiro; Kariya, Shin; Noujima-Harada, Mai; Ohara, Nobuya; Naito, Tomoyuki; Matsumoto, Junya; Noda, Yohei; Okano, Mitsuhiro; Yoshino, Tadashi; Nishizaki, Kazunori.

In: Auris Nasus Larynx, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Ohara, Nobuya

AU - Naito, Tomoyuki

AU - Matsumoto, Junya

AU - Noda, Yohei

AU - Okano, Mitsuhiro

AU - Yoshino, Tadashi

AU - Nishizaki, Kazunori

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