Method for daily administration of low-dose CDDP and 5-FU combined with radiotherapy for oral squamous cell carcinoma

Koji Kishimoto, Takuji Kimura, M. Misaki, Y. Yamada, N. Terakado, T. Matsumura

Research output: Contribution to journalArticle

Abstract

Daily administration of low-dose CDDP and 5-FU combined with radiotherapy was performed in three cases of oral squamous cell carcinoma in aged patients whose general condition was poor. One course of chemotherapy consisted of daily administration of CDDP (10 mg iv, days 1-5) and 5-FU (250-500 mg iv, days 1-5) with radiotherapy (total dose of 60 - 64 Gy). Two or three courses were performed at some interval. There were no severe side-effects except for mucositis. Tumors disappeared in all three cases, and a complete response was achieved in two cases. The method appeared to be safe and useful for oral squamous cell carcinoma patients of advanced age and poor general condition.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume22
Issue number1
Publication statusPublished - 1995

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Keywords

  • 5-FU
  • CDDP
  • radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

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