Methamphetamine may not induce nitric oxide generation in the rat striatum: An In vivo microdialysis study

K. Kashihara, K. Marui, K. Sakai, K. Akiyama, K. Abe

Research output: Contribution to journalArticle

Abstract

We evaluated the effects of methamphetamine (METH) on nitric oxide (NO) generation in the striatum of freely moving rats, by using in vivo microdialysis and by determining the concentration of nitrite and nitrate in perfusates. A intraperitoneal injection of 3 mg/kg METH did not enhance NO metabolite levels in the striatal perfusates. The results indicate that METH does not enhance NO generation in the rat striatum. Present study suggests that NO in the striatum may not be involved in the METH-induced motor activation and dopaminergic neurotoxicity.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalJournal of Brain Science
Volume25
Issue number3-4
Publication statusPublished - Dec 1 1999

ASJC Scopus subject areas

  • Neuroscience(all)

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