Methamphetamine may not induce nitric oxide generation in the rat striatum: An In vivo microdialysis study

K. Kashihara, K. Marui, K. Sakai, K. Akiyama, Koji Abe

Research output: Contribution to journalArticle

Abstract

We evaluated the effects of methamphetamine (METH) on nitric oxide (NO) generation in the striatum of freely moving rats, by using in vivo microdialysis and by determining the concentration of nitrite and nitrate in perfusates. A intraperitoneal injection of 3 mg/kg METH did not enhance NO metabolite levels in the striatal perfusates. The results indicate that METH does not enhance NO generation in the rat striatum. Present study suggests that NO in the striatum may not be involved in the METH-induced motor activation and dopaminergic neurotoxicity.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalJournal of Brain Science
Volume25
Issue number3-4
Publication statusPublished - 1999

Fingerprint

Methamphetamine
Microdialysis
Nitric Oxide
Corpus Striatum
Nitrites
Intraperitoneal Injections
Nitrates

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Methamphetamine may not induce nitric oxide generation in the rat striatum : An In vivo microdialysis study. / Kashihara, K.; Marui, K.; Sakai, K.; Akiyama, K.; Abe, Koji.

In: Journal of Brain Science, Vol. 25, No. 3-4, 1999, p. 115-120.

Research output: Contribution to journalArticle

Kashihara, K. ; Marui, K. ; Sakai, K. ; Akiyama, K. ; Abe, Koji. / Methamphetamine may not induce nitric oxide generation in the rat striatum : An In vivo microdialysis study. In: Journal of Brain Science. 1999 ; Vol. 25, No. 3-4. pp. 115-120.
@article{0297084b9c1141c9b537f1da3792807a,
title = "Methamphetamine may not induce nitric oxide generation in the rat striatum: An In vivo microdialysis study",
abstract = "We evaluated the effects of methamphetamine (METH) on nitric oxide (NO) generation in the striatum of freely moving rats, by using in vivo microdialysis and by determining the concentration of nitrite and nitrate in perfusates. A intraperitoneal injection of 3 mg/kg METH did not enhance NO metabolite levels in the striatal perfusates. The results indicate that METH does not enhance NO generation in the rat striatum. Present study suggests that NO in the striatum may not be involved in the METH-induced motor activation and dopaminergic neurotoxicity.",
author = "K. Kashihara and K. Marui and K. Sakai and K. Akiyama and Koji Abe",
year = "1999",
language = "English",
volume = "25",
pages = "115--120",
journal = "Journal of Brain Science",
issn = "1341-5301",
publisher = "Japan Brain Science Society",
number = "3-4",

}

TY - JOUR

T1 - Methamphetamine may not induce nitric oxide generation in the rat striatum

T2 - An In vivo microdialysis study

AU - Kashihara, K.

AU - Marui, K.

AU - Sakai, K.

AU - Akiyama, K.

AU - Abe, Koji

PY - 1999

Y1 - 1999

N2 - We evaluated the effects of methamphetamine (METH) on nitric oxide (NO) generation in the striatum of freely moving rats, by using in vivo microdialysis and by determining the concentration of nitrite and nitrate in perfusates. A intraperitoneal injection of 3 mg/kg METH did not enhance NO metabolite levels in the striatal perfusates. The results indicate that METH does not enhance NO generation in the rat striatum. Present study suggests that NO in the striatum may not be involved in the METH-induced motor activation and dopaminergic neurotoxicity.

AB - We evaluated the effects of methamphetamine (METH) on nitric oxide (NO) generation in the striatum of freely moving rats, by using in vivo microdialysis and by determining the concentration of nitrite and nitrate in perfusates. A intraperitoneal injection of 3 mg/kg METH did not enhance NO metabolite levels in the striatal perfusates. The results indicate that METH does not enhance NO generation in the rat striatum. Present study suggests that NO in the striatum may not be involved in the METH-induced motor activation and dopaminergic neurotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=0033282709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033282709&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0033282709

VL - 25

SP - 115

EP - 120

JO - Journal of Brain Science

JF - Journal of Brain Science

SN - 1341-5301

IS - 3-4

ER -