We evaluated the effects of methamphetamine (METH) on nitric oxide (NO) generation in the striatum of freely moving rats, by using in vivo microdialysis and by determining the concentration of nitrite and nitrate in perfusates. A intraperitoneal injection of 3 mg/kg METH did not enhance NO metabolite levels in the striatal perfusates. The results indicate that METH does not enhance NO generation in the rat striatum. Present study suggests that NO in the striatum may not be involved in the METH-induced motor activation and dopaminergic neurotoxicity.
|Number of pages||6|
|Journal||Journal of Brain Science|
|Publication status||Published - Dec 1 1999|
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