Methamphetamine-induced neurotoxicity in mouse brain is attenuated by ketoprofen, a non-steroidal anti-inflammatory drug

Masato Asanuma, Takeshi Tsuji, Ikuko Miyazaki, Ko Miyoshi, Norio Ogawa

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

We examined effects of non-steroidal anti-inflammatory drugs (NSAIDs) on methamphetamine (METH)-induced neurotoxicity. Marked reduction of dopamine transporter-positive signals and accumulation of microglial cells in the striatum after METH injections (4 mg/kg ×4, i.p. with 2 h-interval) were significantly and dose-dependently attenuated by four injections of ketoprofen (2 or 5 mg/kg ×4, s.c.) given 30 min prior to each METH injection, but not by either a low or high dose of aspirin. The present results suggest that the protective effects of ketoprofen against METH-induced neurotoxicity and microgliosis might be based on its inhibitory activity on inflammatory response or on microglia activation, but not on its cyclooxygenase-inhibiting property. This provides a possible new strategy against METH-induced neurotoxicity using commonly used NSAIDs.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalNeuroscience Letters
Volume352
Issue number1
DOIs
Publication statusPublished - Nov 27 2003

Keywords

  • Aspirin
  • Ketoprofen
  • Methamphetamine
  • Microglia
  • Neurotoxicity
  • Non-steroidal anti-inflammatory drug

ASJC Scopus subject areas

  • Neuroscience(all)

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