TY - JOUR
T1 - Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic mice
AU - Asanuma, Masato
AU - Miyazaki, Ikuko
AU - Higashi, Youichirou
AU - Cadet, Jean Lud
AU - Ogawa, Norio
N1 - Funding Information:
This work was supported, in part, by the Intramural Program of the NIDA, and by Grants-in-aid for the Encouragement of Young Scientists (A) from the Japanese Ministry of Education, Culture, Sports, Science and Technology, and by Grants-in-aid for Research on Pharmaceutical and Medical Safety, for Brain Science, and for Comprehensive Research on Aging and Health from the Japanese Ministry of Health, Labour and Welfare.
PY - 2002/6/14
Y1 - 2002/6/14
N2 - The striatal DNA-binding activities of p53 as a transcription factor were gradually increased at several days after a single methamphetamine (METH) injection, while they were more rapidly increased within several hours after repeated METH injections (×4 with a 2 h interval). The elevation of striatal p53 DNA-binding after repeated METH injections was markedly attenuated in Cu,Zn-superoxide dismutase transgenic mice, but not affected by treatments with N-methyl-D-aspartate or D1 receptor antagonists. The present results suggest that METH-induced production of reactive oxygen species activates striatal p53 DNA-binding activity; this, in turn, may activate other downstream pathways that are responsible for chronic neurotoxicity of METH.
AB - The striatal DNA-binding activities of p53 as a transcription factor were gradually increased at several days after a single methamphetamine (METH) injection, while they were more rapidly increased within several hours after repeated METH injections (×4 with a 2 h interval). The elevation of striatal p53 DNA-binding after repeated METH injections was markedly attenuated in Cu,Zn-superoxide dismutase transgenic mice, but not affected by treatments with N-methyl-D-aspartate or D1 receptor antagonists. The present results suggest that METH-induced production of reactive oxygen species activates striatal p53 DNA-binding activity; this, in turn, may activate other downstream pathways that are responsible for chronic neurotoxicity of METH.
KW - DNA-binding activity
KW - Methamphetamine
KW - Reactive oxygen species
KW - Superoxide dismutase
KW - p53
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U2 - 10.1016/S0304-3940(02)00291-4
DO - 10.1016/S0304-3940(02)00291-4
M3 - Article
C2 - 12044653
AN - SCOPUS:0037076873
VL - 325
SP - 191
EP - 194
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -