Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic mice

Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Jean Lud Cadet, Norio Ogawa

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The striatal DNA-binding activities of p53 as a transcription factor were gradually increased at several days after a single methamphetamine (METH) injection, while they were more rapidly increased within several hours after repeated METH injections (×4 with a 2 h interval). The elevation of striatal p53 DNA-binding after repeated METH injections was markedly attenuated in Cu,Zn-superoxide dismutase transgenic mice, but not affected by treatments with N-methyl-D-aspartate or D1 receptor antagonists. The present results suggest that METH-induced production of reactive oxygen species activates striatal p53 DNA-binding activity; this, in turn, may activate other downstream pathways that are responsible for chronic neurotoxicity of METH.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalNeuroscience Letters
Volume325
Issue number3
DOIs
Publication statusPublished - Jun 14 2002

Keywords

  • DNA-binding activity
  • Methamphetamine
  • Reactive oxygen species
  • Superoxide dismutase
  • p53

ASJC Scopus subject areas

  • Neuroscience(all)

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