Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice

Masato Asanuma, Jean Lud Cadet

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalMolecular Brain Research
Volume60
Issue number2
DOIs
Publication statusPublished - Oct 1 1998
Externally publishedYes

Fingerprint

Corpus Striatum
Methamphetamine
Transgenic Mice
Superoxide Dismutase
DNA
Injections
Gene Dosage
Poisons
Reactive Oxygen Species
Pharmaceutical Preparations

Keywords

  • Methamphetamine
  • NF-κB
  • Reactive oxygen species
  • Superoxide dismutase
  • Transcription factor
  • Transgenic mice

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice. / Asanuma, Masato; Cadet, Jean Lud.

In: Molecular Brain Research, Vol. 60, No. 2, 01.10.1998, p. 305-309.

Research output: Contribution to journalArticle

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