Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice

Masato Asanuma, Jean Lud Cadet

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalMolecular Brain Research
Volume60
Issue number2
DOIs
Publication statusPublished - Oct 1 1998
Externally publishedYes

Keywords

  • Methamphetamine
  • NF-κB
  • Reactive oxygen species
  • Superoxide dismutase
  • Transcription factor
  • Transgenic mice

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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