TY - JOUR
T1 - Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice
AU - Asanuma, Masato
AU - Cadet, Jean Lud
N1 - Funding Information:
This work was supported by the Intramural Program of the NIDA. The authors thank the staff of Animal Care Facility at Intramural Research Program of NIH/ NIDA for the impeccable care of the animals. The authors are very grateful to C.J. Epstein and E. Carlson for initially providing breeding pairs of Cu,Zn-SOD-Tg mice.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/10/1
Y1 - 1998/10/1
N2 - Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.
AB - Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.
KW - Methamphetamine
KW - NF-κB
KW - Reactive oxygen species
KW - Superoxide dismutase
KW - Transcription factor
KW - Transgenic mice
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U2 - 10.1016/S0169-328X(98)00188-0
DO - 10.1016/S0169-328X(98)00188-0
M3 - Article
C2 - 9757070
AN - SCOPUS:0032189943
VL - 60
SP - 305
EP - 309
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 2
ER -