Abstract
Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.
| Original language | English |
|---|---|
| Pages (from-to) | 305-309 |
| Number of pages | 5 |
| Journal | Molecular Brain Research |
| Volume | 60 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Oct 1 1998 |
| Externally published | Yes |
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Keywords
- Methamphetamine
- NF-κB
- Reactive oxygen species
- Superoxide dismutase
- Transcription factor
- Transgenic mice
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
Cite this
Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice. / Asanuma, Masato; Cadet, Jean Lud.
In: Molecular Brain Research, Vol. 60, No. 2, 01.10.1998, p. 305-309.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice
AU - Asanuma, Masato
AU - Cadet, Jean Lud
PY - 1998/10/1
Y1 - 1998/10/1
N2 - Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.
AB - Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.
KW - Methamphetamine
KW - NF-κB
KW - Reactive oxygen species
KW - Superoxide dismutase
KW - Transcription factor
KW - Transgenic mice
UR - http://www.scopus.com/inward/record.url?scp=0032189943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032189943&partnerID=8YFLogxK
U2 - 10.1016/S0169-328X(98)00188-0
DO - 10.1016/S0169-328X(98)00188-0
M3 - Article
C2 - 9757070
AN - SCOPUS:0032189943
VL - 60
SP - 305
EP - 309
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -