Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice

Masato Asanuma; Jean Lud Cadet

doi:10.1016/S0169-328X(98)00188-0

Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice

Masato Asanuma, Jean Lud Cadet

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.

Original language	English
Pages (from-to)	305-309
Number of pages	5
Journal	Molecular Brain Research
Volume	60
Issue number	2
DOIs	https://doi.org/10.1016/S0169-328X(98)00188-0
Publication status	Published - Oct 1 1998
Externally published	Yes

Keywords

Methamphetamine
NF-κB
Reactive oxygen species
Superoxide dismutase
Transcription factor
Transgenic mice

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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title = "Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice",

abstract = "Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.",

keywords = "Methamphetamine, NF-κB, Reactive oxygen species, Superoxide dismutase, Transcription factor, Transgenic mice",

author = "Masato Asanuma and Cadet, {Jean Lud}",

note = "Funding Information: This work was supported by the Intramural Program of the NIDA. The authors thank the staff of Animal Care Facility at Intramural Research Program of NIH/ NIDA for the impeccable care of the animals. The authors are very grateful to C.J. Epstein and E. Carlson for initially providing breeding pairs of Cu,Zn-SOD-Tg mice. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "1998",

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doi = "10.1016/S0169-328X(98)00188-0",

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AU - Asanuma, Masato

AU - Cadet, Jean Lud

N1 - Funding Information: This work was supported by the Intramural Program of the NIDA. The authors thank the staff of Animal Care Facility at Intramural Research Program of NIH/ NIDA for the impeccable care of the animals. The authors are very grateful to C.J. Epstein and E. Carlson for initially providing breeding pairs of Cu,Zn-SOD-Tg mice. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 1998/10/1

Y1 - 1998/10/1

N2 - Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.

AB - Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.

KW - Methamphetamine

KW - NF-κB

KW - Reactive oxygen species

KW - Superoxide dismutase

KW - Transcription factor

KW - Transgenic mice

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Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice

Abstract

Keywords

ASJC Scopus subject areas

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