Abstract
Methamphetamine injection (x4 with 2-h interval) caused dose-dependent activation of striatal NF-κB activity. Striatal NF-κB binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. x4). This induction of striatal NF-κB activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-κB DNA-binding during this drug-induced toxic process.
Original language | English |
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Pages (from-to) | 305-309 |
Number of pages | 5 |
Journal | Molecular Brain Research |
Volume | 60 |
Issue number | 2 |
DOIs | |
Publication status | Published - Oct 1 1998 |
Externally published | Yes |
Keywords
- Methamphetamine
- NF-κB
- Reactive oxygen species
- Superoxide dismutase
- Transcription factor
- Transgenic mice
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience