Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44

Nobuhiro Kawasaki, Yoshinobu Matsuo, Tadashi Yoshino, Hiroyuki Yanai, Takashi Oka, Norihiro Teramoto, Cao Liu, Eisaku Kondo, Jun Minowada, Tadaatsu Akagi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To investigate whether the lymphocyte homing receptors, adhesion molecules regulating normal lymphocyte traffic, influence the dissemination of lymphoma cells, 24 lymphoma/leukemia cell lines were inoculated into SCID mice subcutaneously, and the correlation between the expression of the adhesion molecules and the metastatic potential of the cell lines was examined. Among the six adhesion molecules examined (LFA-1, ICAM-1, CLA, VLA-4, L-selectin and CD44), L-selectin increased the incidence of lymph node metastasis, and CD44 expression was related to both lymph node and organ (hematogenous) metastasis. A monoclonal antibody to the standard form of CD44 (CD44s), Hermes-3, inhibited the local growth and remote metastasis of CD44+ cell lines. Thus, it is concluded that at least CD44s expression is important in both lymphatic and hematogenous metastasis.

Original languageEnglish
Pages (from-to)1070-1077
Number of pages8
JournalJapanese Journal of Cancer Research
Volume87
Issue number10
DOIs
Publication statusPublished - Oct 1996

Keywords

  • Adhesion molecule
  • Animal model
  • Hermes-3
  • Malignant lymphoma
  • Metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44'. Together they form a unique fingerprint.

  • Cite this