Metastasis-related genes in prostate cancer

C. H. Bangma, Yasutomo Nasu, C. Ren, T. C. Thompson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The identification of genes specifically related to the development of metastatic disease in prostate cancer is complicated by tumor cell heterogeneity and the presence of expressed sequences that are not related to metastasis. A system was designed to minimize these complications using differential display-polymerase chain reaction (DD-PCR) together with genetically paired cell lines derived from primary mouse prostate cancer and their associated metastases generated in vivo by the metastatic mouse prostate cancer reconstitution model. Using this system, a number of metastasis-related sequences were identified, including a cDNA that encodes caveolin-1.

Original languageEnglish
Pages (from-to)422-427
Number of pages6
JournalSeminars in Oncology
Volume26
Issue number4
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Prostatic Neoplasms
Neoplasm Metastasis
Genes
Caveolin 1
Complementary DNA
Cell Line
Polymerase Chain Reaction
Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Bangma, C. H., Nasu, Y., Ren, C., & Thompson, T. C. (1999). Metastasis-related genes in prostate cancer. Seminars in Oncology, 26(4), 422-427.

Metastasis-related genes in prostate cancer. / Bangma, C. H.; Nasu, Yasutomo; Ren, C.; Thompson, T. C.

In: Seminars in Oncology, Vol. 26, No. 4, 1999, p. 422-427.

Research output: Contribution to journalArticle

Bangma, CH, Nasu, Y, Ren, C & Thompson, TC 1999, 'Metastasis-related genes in prostate cancer', Seminars in Oncology, vol. 26, no. 4, pp. 422-427.
Bangma CH, Nasu Y, Ren C, Thompson TC. Metastasis-related genes in prostate cancer. Seminars in Oncology. 1999;26(4):422-427.
Bangma, C. H. ; Nasu, Yasutomo ; Ren, C. ; Thompson, T. C. / Metastasis-related genes in prostate cancer. In: Seminars in Oncology. 1999 ; Vol. 26, No. 4. pp. 422-427.
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