Metastasis-related genes in prostate cancer

C. H. Bangma, Y. Nasu, C. Ren, T. C. Thompson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The identification of genes specifically related to the development of metastatic disease in prostate cancer is complicated by tumor cell heterogeneity and the presence of expressed sequences that are not related to metastasis. A system was designed to minimize these complications using differential display-polymerase chain reaction (DD-PCR) together with genetically paired cell lines derived from primary mouse prostate cancer and their associated metastases generated in vivo by the metastatic mouse prostate cancer reconstitution model. Using this system, a number of metastasis-related sequences were identified, including a cDNA that encodes caveolin-1.

Original languageEnglish
Pages (from-to)422-427
Number of pages6
JournalSeminars in Oncology
Volume26
Issue number4
Publication statusPublished - Sep 8 1999
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology

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    Bangma, C. H., Nasu, Y., Ren, C., & Thompson, T. C. (1999). Metastasis-related genes in prostate cancer. Seminars in Oncology, 26(4), 422-427.