METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research

Martin Dichgans, Joanna Wardlaw, Eric Smith, Vera Zietemann, Sudha Seshadri, Perminder Sachdev, Geert Jan Biessels, Franz Fazekas, Oscar Benavente, Leonardo Pantoni, Frank Erik De Leeuw, Bo Norrving, Paul Matthews, Christopher Chen, Vincent Mok, Marco Düring, Will Whiteley, Kirsten Shuler, Alvaro Alonso, Sandra E. BlackCarol Brayne, Hugues Chabriat, Charlotte Cordonnier, Fergus Doubal, Emrah Duzel, Michael Ewers, Richard Frayne, Vladimir Hachinski, Mohammad Arfan Ikram, Frank Jessen, Eric Jouvent, Jennifer Linn, John O'Brien, Robert van Oostenbrugge, Rainer Malik, Bernard Mazoyer, Reinhold Schmidt, Luciano A. Sposato, Blossom Stephan, Richard H. Swartz, Meike Vernooij, Anand Viswanathan, David Werring, Koji Abe, Louise Allan, Francesco Arba, H. C. Diener, S. Davis, G. Hankey, K. R. Lees, B. Ovbiagele, C. Weir, Hee Joon Bae, Philip MW Bath, Regis Bordet, Monique Breteler, Seong Choi, Ian Deary, Charles DeCarli, Klaus Ebmeier, Lei Feng, Steven M. Greenberg, Masafumi Ihara, Rajesh Kalaria, San Yun Kim, Jae Sung Lim, Richard I. Lindley, Gillian Mead, Alison Murray, Terry Quinn, Craig Ritchie, Ralph Sacco, Rustam Al-Shahi Salman, Nikola Sprigg, Cathie Sudlow, Alan Thomas, Martin van Boxtel, Jeroen van der Grond, Aad van der Lugt, Yuan Han Yang

Research output: Contribution to journalShort survey

24 Citations (Scopus)

Abstract

Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically “silent” cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors. New large collaborative studies with long follow-up are expensive and time consuming, yet substantial data to advance the field are available. In an initiative funded by the Joint Programme for Neurodegenerative Disease Research, 55 international experts surveyed and assessed available data, starting with European cohorts, to promote data sharing to advance understanding of how vascular disease affects brain structure and function, optimize methods for cerebrovascular disease in neurodegeneration research, and focus future research on gaps in knowledge. Here, we summarize the results and recommendations from this initiative. We identified data from over 90 studies, including over 660,000 participants, many being additional to neurodegeneration data initiatives. The enthusiastic response means that cohorts from North America, Australasia, and the Asia Pacific Region are included, creating a truly global, collaborative, data sharing platform, linked to major national dementia initiatives. Furthermore, the revised World Health Organization International Classification of Diseases version 11 should facilitate recognition of vascular-related brain damage by creating one category for all cerebrovascular disease presentations and thus accelerate identification of targets for dementia prevention.

Original languageEnglish
Pages (from-to)1235-1249
Number of pages15
JournalAlzheimer's and Dementia
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Cerebrovascular Disorders
Vascular Diseases
Neurodegenerative Diseases
Dementia
Research
Information Dissemination
Blood Vessels
Australasia
Brain
International Classification of Diseases
North America
Health Personnel
Alzheimer Disease
Stroke
Cognitive Dysfunction
Incidence
Therapeutics

Keywords

  • Cerebrovascular disease
  • Dementia
  • Neurodegeneration, Cohorts, Survey
  • Small vessel disease

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration : An initiative of the Joint Programme for Neurodegenerative Disease Research. / Dichgans, Martin; Wardlaw, Joanna; Smith, Eric; Zietemann, Vera; Seshadri, Sudha; Sachdev, Perminder; Biessels, Geert Jan; Fazekas, Franz; Benavente, Oscar; Pantoni, Leonardo; De Leeuw, Frank Erik; Norrving, Bo; Matthews, Paul; Chen, Christopher; Mok, Vincent; Düring, Marco; Whiteley, Will; Shuler, Kirsten; Alonso, Alvaro; Black, Sandra E.; Brayne, Carol; Chabriat, Hugues; Cordonnier, Charlotte; Doubal, Fergus; Duzel, Emrah; Ewers, Michael; Frayne, Richard; Hachinski, Vladimir; Ikram, Mohammad Arfan; Jessen, Frank; Jouvent, Eric; Linn, Jennifer; O'Brien, John; van Oostenbrugge, Robert; Malik, Rainer; Mazoyer, Bernard; Schmidt, Reinhold; Sposato, Luciano A.; Stephan, Blossom; Swartz, Richard H.; Vernooij, Meike; Viswanathan, Anand; Werring, David; Abe, Koji; Allan, Louise; Arba, Francesco; Diener, H. C.; Davis, S.; Hankey, G.; Lees, K. R.; Ovbiagele, B.; Weir, C.; Bae, Hee Joon; Bath, Philip MW; Bordet, Regis; Breteler, Monique; Choi, Seong; Deary, Ian; DeCarli, Charles; Ebmeier, Klaus; Feng, Lei; Greenberg, Steven M.; Ihara, Masafumi; Kalaria, Rajesh; Kim, San Yun; Lim, Jae Sung; Lindley, Richard I.; Mead, Gillian; Murray, Alison; Quinn, Terry; Ritchie, Craig; Sacco, Ralph; Al-Shahi Salman, Rustam; Sprigg, Nikola; Sudlow, Cathie; Thomas, Alan; van Boxtel, Martin; van der Grond, Jeroen; van der Lugt, Aad; Yang, Yuan Han.

In: Alzheimer's and Dementia, Vol. 12, No. 12, 01.12.2016, p. 1235-1249.

Research output: Contribution to journalShort survey

Dichgans, M, Wardlaw, J, Smith, E, Zietemann, V, Seshadri, S, Sachdev, P, Biessels, GJ, Fazekas, F, Benavente, O, Pantoni, L, De Leeuw, FE, Norrving, B, Matthews, P, Chen, C, Mok, V, Düring, M, Whiteley, W, Shuler, K, Alonso, A, Black, SE, Brayne, C, Chabriat, H, Cordonnier, C, Doubal, F, Duzel, E, Ewers, M, Frayne, R, Hachinski, V, Ikram, MA, Jessen, F, Jouvent, E, Linn, J, O'Brien, J, van Oostenbrugge, R, Malik, R, Mazoyer, B, Schmidt, R, Sposato, LA, Stephan, B, Swartz, RH, Vernooij, M, Viswanathan, A, Werring, D, Abe, K, Allan, L, Arba, F, Diener, HC, Davis, S, Hankey, G, Lees, KR, Ovbiagele, B, Weir, C, Bae, HJ, Bath, PMW, Bordet, R, Breteler, M, Choi, S, Deary, I, DeCarli, C, Ebmeier, K, Feng, L, Greenberg, SM, Ihara, M, Kalaria, R, Kim, SY, Lim, JS, Lindley, RI, Mead, G, Murray, A, Quinn, T, Ritchie, C, Sacco, R, Al-Shahi Salman, R, Sprigg, N, Sudlow, C, Thomas, A, van Boxtel, M, van der Grond, J, van der Lugt, A & Yang, YH 2016, 'METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research', Alzheimer's and Dementia, vol. 12, no. 12, pp. 1235-1249. https://doi.org/10.1016/j.jalz.2016.06.004
Dichgans, Martin ; Wardlaw, Joanna ; Smith, Eric ; Zietemann, Vera ; Seshadri, Sudha ; Sachdev, Perminder ; Biessels, Geert Jan ; Fazekas, Franz ; Benavente, Oscar ; Pantoni, Leonardo ; De Leeuw, Frank Erik ; Norrving, Bo ; Matthews, Paul ; Chen, Christopher ; Mok, Vincent ; Düring, Marco ; Whiteley, Will ; Shuler, Kirsten ; Alonso, Alvaro ; Black, Sandra E. ; Brayne, Carol ; Chabriat, Hugues ; Cordonnier, Charlotte ; Doubal, Fergus ; Duzel, Emrah ; Ewers, Michael ; Frayne, Richard ; Hachinski, Vladimir ; Ikram, Mohammad Arfan ; Jessen, Frank ; Jouvent, Eric ; Linn, Jennifer ; O'Brien, John ; van Oostenbrugge, Robert ; Malik, Rainer ; Mazoyer, Bernard ; Schmidt, Reinhold ; Sposato, Luciano A. ; Stephan, Blossom ; Swartz, Richard H. ; Vernooij, Meike ; Viswanathan, Anand ; Werring, David ; Abe, Koji ; Allan, Louise ; Arba, Francesco ; Diener, H. C. ; Davis, S. ; Hankey, G. ; Lees, K. R. ; Ovbiagele, B. ; Weir, C. ; Bae, Hee Joon ; Bath, Philip MW ; Bordet, Regis ; Breteler, Monique ; Choi, Seong ; Deary, Ian ; DeCarli, Charles ; Ebmeier, Klaus ; Feng, Lei ; Greenberg, Steven M. ; Ihara, Masafumi ; Kalaria, Rajesh ; Kim, San Yun ; Lim, Jae Sung ; Lindley, Richard I. ; Mead, Gillian ; Murray, Alison ; Quinn, Terry ; Ritchie, Craig ; Sacco, Ralph ; Al-Shahi Salman, Rustam ; Sprigg, Nikola ; Sudlow, Cathie ; Thomas, Alan ; van Boxtel, Martin ; van der Grond, Jeroen ; van der Lugt, Aad ; Yang, Yuan Han. / METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration : An initiative of the Joint Programme for Neurodegenerative Disease Research. In: Alzheimer's and Dementia. 2016 ; Vol. 12, No. 12. pp. 1235-1249.
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abstract = "Dementia is a global problem and major target for health care providers. Although up to 45{\%} of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically “silent” cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors. New large collaborative studies with long follow-up are expensive and time consuming, yet substantial data to advance the field are available. In an initiative funded by the Joint Programme for Neurodegenerative Disease Research, 55 international experts surveyed and assessed available data, starting with European cohorts, to promote data sharing to advance understanding of how vascular disease affects brain structure and function, optimize methods for cerebrovascular disease in neurodegeneration research, and focus future research on gaps in knowledge. Here, we summarize the results and recommendations from this initiative. We identified data from over 90 studies, including over 660,000 participants, many being additional to neurodegeneration data initiatives. The enthusiastic response means that cohorts from North America, Australasia, and the Asia Pacific Region are included, creating a truly global, collaborative, data sharing platform, linked to major national dementia initiatives. Furthermore, the revised World Health Organization International Classification of Diseases version 11 should facilitate recognition of vascular-related brain damage by creating one category for all cerebrovascular disease presentations and thus accelerate identification of targets for dementia prevention.",
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T1 - METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration

T2 - An initiative of the Joint Programme for Neurodegenerative Disease Research

AU - Dichgans, Martin

AU - Wardlaw, Joanna

AU - Smith, Eric

AU - Zietemann, Vera

AU - Seshadri, Sudha

AU - Sachdev, Perminder

AU - Biessels, Geert Jan

AU - Fazekas, Franz

AU - Benavente, Oscar

AU - Pantoni, Leonardo

AU - De Leeuw, Frank Erik

AU - Norrving, Bo

AU - Matthews, Paul

AU - Chen, Christopher

AU - Mok, Vincent

AU - Düring, Marco

AU - Whiteley, Will

AU - Shuler, Kirsten

AU - Alonso, Alvaro

AU - Black, Sandra E.

AU - Brayne, Carol

AU - Chabriat, Hugues

AU - Cordonnier, Charlotte

AU - Doubal, Fergus

AU - Duzel, Emrah

AU - Ewers, Michael

AU - Frayne, Richard

AU - Hachinski, Vladimir

AU - Ikram, Mohammad Arfan

AU - Jessen, Frank

AU - Jouvent, Eric

AU - Linn, Jennifer

AU - O'Brien, John

AU - van Oostenbrugge, Robert

AU - Malik, Rainer

AU - Mazoyer, Bernard

AU - Schmidt, Reinhold

AU - Sposato, Luciano A.

AU - Stephan, Blossom

AU - Swartz, Richard H.

AU - Vernooij, Meike

AU - Viswanathan, Anand

AU - Werring, David

AU - Abe, Koji

AU - Allan, Louise

AU - Arba, Francesco

AU - Diener, H. C.

AU - Davis, S.

AU - Hankey, G.

AU - Lees, K. R.

AU - Ovbiagele, B.

AU - Weir, C.

AU - Bae, Hee Joon

AU - Bath, Philip MW

AU - Bordet, Regis

AU - Breteler, Monique

AU - Choi, Seong

AU - Deary, Ian

AU - DeCarli, Charles

AU - Ebmeier, Klaus

AU - Feng, Lei

AU - Greenberg, Steven M.

AU - Ihara, Masafumi

AU - Kalaria, Rajesh

AU - Kim, San Yun

AU - Lim, Jae Sung

AU - Lindley, Richard I.

AU - Mead, Gillian

AU - Murray, Alison

AU - Quinn, Terry

AU - Ritchie, Craig

AU - Sacco, Ralph

AU - Al-Shahi Salman, Rustam

AU - Sprigg, Nikola

AU - Sudlow, Cathie

AU - Thomas, Alan

AU - van Boxtel, Martin

AU - van der Grond, Jeroen

AU - van der Lugt, Aad

AU - Yang, Yuan Han

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N2 - Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically “silent” cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors. New large collaborative studies with long follow-up are expensive and time consuming, yet substantial data to advance the field are available. In an initiative funded by the Joint Programme for Neurodegenerative Disease Research, 55 international experts surveyed and assessed available data, starting with European cohorts, to promote data sharing to advance understanding of how vascular disease affects brain structure and function, optimize methods for cerebrovascular disease in neurodegeneration research, and focus future research on gaps in knowledge. Here, we summarize the results and recommendations from this initiative. We identified data from over 90 studies, including over 660,000 participants, many being additional to neurodegeneration data initiatives. The enthusiastic response means that cohorts from North America, Australasia, and the Asia Pacific Region are included, creating a truly global, collaborative, data sharing platform, linked to major national dementia initiatives. Furthermore, the revised World Health Organization International Classification of Diseases version 11 should facilitate recognition of vascular-related brain damage by creating one category for all cerebrovascular disease presentations and thus accelerate identification of targets for dementia prevention.

AB - Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically “silent” cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors. New large collaborative studies with long follow-up are expensive and time consuming, yet substantial data to advance the field are available. In an initiative funded by the Joint Programme for Neurodegenerative Disease Research, 55 international experts surveyed and assessed available data, starting with European cohorts, to promote data sharing to advance understanding of how vascular disease affects brain structure and function, optimize methods for cerebrovascular disease in neurodegeneration research, and focus future research on gaps in knowledge. Here, we summarize the results and recommendations from this initiative. We identified data from over 90 studies, including over 660,000 participants, many being additional to neurodegeneration data initiatives. The enthusiastic response means that cohorts from North America, Australasia, and the Asia Pacific Region are included, creating a truly global, collaborative, data sharing platform, linked to major national dementia initiatives. Furthermore, the revised World Health Organization International Classification of Diseases version 11 should facilitate recognition of vascular-related brain damage by creating one category for all cerebrovascular disease presentations and thus accelerate identification of targets for dementia prevention.

KW - Cerebrovascular disease

KW - Dementia

KW - Neurodegeneration, Cohorts, Survey

KW - Small vessel disease

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