Metabolism of highly persistent PCB congener, 2,4,5,2′,4′,5′-hexachlorobiphenyl, by human CYP2B6

N. Ariyoshi, K. Oguri, N. Koga, H. Yoshimura, Y. Funae

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Metabolism of 2,4,5,2′,4′,5′-hexachlorobiphenyl was studied with cDNA-expressed human P450 2B isoform, CYP2B6. 3-Hydroxy-2,4,5,2′,4′,5′-hexachlorobiphenyl was identified as a major metabolite, and the formation activity was compared with that of dog CYP2B11 and guinea pig P450GP-1. The activity of 3-hydroxylation was comparable with that of P450GP-1, but one-tenth of CYP2B11. These results indicate that P450 2B in humans as well as other animal species can metabolize 2,4,5,2′,4′,5′-hexachlorobiphenyl, and the reason why this PCB congener remained most abundantly in human bodies is discussed.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume212
Issue number2
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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