Metabolism of 2,4,5,2′,4′,5′-hexachlorobiphenyl was studied with cDNA-expressed human P450 2B isoform, CYP2B6. 3-Hydroxy-2,4,5,2′,4′,5′-hexachlorobiphenyl was identified as a major metabolite, and the formation activity was compared with that of dog CYP2B11 and guinea pig P450GP-1. The activity of 3-hydroxylation was comparable with that of P450GP-1, but one-tenth of CYP2B11. These results indicate that P450 2B in humans as well as other animal species can metabolize 2,4,5,2′,4′,5′-hexachlorobiphenyl, and the reason why this PCB congener remained most abundantly in human bodies is discussed.
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Jan 1 1995|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology