Metabolism of chloral hydrate in the anoxic perfused liver

Toshihiro Kawamoto, Tatsuya Hobara, Tatsuya Aoki, Haruo Kobayashi, Susumu Iwamoto, Tsunemi Sakai, Takehito Takano, Yoshifumi Miyazaki, Akihisa Imamura, Keiki Ogino

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalToxicology Letters
Volume40
Issue number3
DOIs
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Chloral Hydrate
Trichloroacetic Acid
Metabolism
Liver
Oxygen
Metabolites
Pyruvic Acid
Lactic Acid
Hemoglobins
Perfusion
2,2,2-trichloroethanol
Oxidation

Keywords

  • Anoxia
  • Chloral hydrate: Trichloroethanol
  • Drug metabolism
  • Liver
  • Perfusion
  • Trichloroacetic acid

ASJC Scopus subject areas

  • Toxicology

Cite this

Kawamoto, T., Hobara, T., Aoki, T., Kobayashi, H., Iwamoto, S., Sakai, T., ... Ogino, K. (1988). Metabolism of chloral hydrate in the anoxic perfused liver. Toxicology Letters, 40(3), 225-231. https://doi.org/10.1016/0378-4274(88)90045-8

Metabolism of chloral hydrate in the anoxic perfused liver. / Kawamoto, Toshihiro; Hobara, Tatsuya; Aoki, Tatsuya; Kobayashi, Haruo; Iwamoto, Susumu; Sakai, Tsunemi; Takano, Takehito; Miyazaki, Yoshifumi; Imamura, Akihisa; Ogino, Keiki.

In: Toxicology Letters, Vol. 40, No. 3, 1988, p. 225-231.

Research output: Contribution to journalArticle

Kawamoto, T, Hobara, T, Aoki, T, Kobayashi, H, Iwamoto, S, Sakai, T, Takano, T, Miyazaki, Y, Imamura, A & Ogino, K 1988, 'Metabolism of chloral hydrate in the anoxic perfused liver', Toxicology Letters, vol. 40, no. 3, pp. 225-231. https://doi.org/10.1016/0378-4274(88)90045-8
Kawamoto T, Hobara T, Aoki T, Kobayashi H, Iwamoto S, Sakai T et al. Metabolism of chloral hydrate in the anoxic perfused liver. Toxicology Letters. 1988;40(3):225-231. https://doi.org/10.1016/0378-4274(88)90045-8
Kawamoto, Toshihiro ; Hobara, Tatsuya ; Aoki, Tatsuya ; Kobayashi, Haruo ; Iwamoto, Susumu ; Sakai, Tsunemi ; Takano, Takehito ; Miyazaki, Yoshifumi ; Imamura, Akihisa ; Ogino, Keiki. / Metabolism of chloral hydrate in the anoxic perfused liver. In: Toxicology Letters. 1988 ; Vol. 40, No. 3. pp. 225-231.
@article{69e67f6d0d6c478d8dc1ae7076cc763b,
title = "Metabolism of chloral hydrate in the anoxic perfused liver",
abstract = "The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80{\%} of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14{\%} of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.",
keywords = "Anoxia, Chloral hydrate: Trichloroethanol, Drug metabolism, Liver, Perfusion, Trichloroacetic acid",
author = "Toshihiro Kawamoto and Tatsuya Hobara and Tatsuya Aoki and Haruo Kobayashi and Susumu Iwamoto and Tsunemi Sakai and Takehito Takano and Yoshifumi Miyazaki and Akihisa Imamura and Keiki Ogino",
year = "1988",
doi = "10.1016/0378-4274(88)90045-8",
language = "English",
volume = "40",
pages = "225--231",
journal = "Toxicology Letters",
issn = "0378-4274",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - Metabolism of chloral hydrate in the anoxic perfused liver

AU - Kawamoto, Toshihiro

AU - Hobara, Tatsuya

AU - Aoki, Tatsuya

AU - Kobayashi, Haruo

AU - Iwamoto, Susumu

AU - Sakai, Tsunemi

AU - Takano, Takehito

AU - Miyazaki, Yoshifumi

AU - Imamura, Akihisa

AU - Ogino, Keiki

PY - 1988

Y1 - 1988

N2 - The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

AB - The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

KW - Anoxia

KW - Chloral hydrate: Trichloroethanol

KW - Drug metabolism

KW - Liver

KW - Perfusion

KW - Trichloroacetic acid

UR - http://www.scopus.com/inward/record.url?scp=0023911117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023911117&partnerID=8YFLogxK

U2 - 10.1016/0378-4274(88)90045-8

DO - 10.1016/0378-4274(88)90045-8

M3 - Article

C2 - 3354006

AN - SCOPUS:0023911117

VL - 40

SP - 225

EP - 231

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

IS - 3

ER -