Metabolism of chloral hydrate in the anoxic perfused liver

Toshihiro Kawamoto, Tatsuya Hobara, Tatsuya Aoki, Haruo Kobayashi, Susumu Iwamoto, Tsunemi Sakai, Takehito Takano, Yoshifumi Miyazaki, Akihisa Imamura, Keiki Ogino

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8 Citations (Scopus)

Abstract

The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalToxicology Letters
Volume40
Issue number3
DOIs
Publication statusPublished - Mar 1988

Keywords

  • Anoxia
  • Chloral hydrate: Trichloroethanol
  • Drug metabolism
  • Liver
  • Perfusion
  • Trichloroacetic acid

ASJC Scopus subject areas

  • Toxicology

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    Kawamoto, T., Hobara, T., Aoki, T., Kobayashi, H., Iwamoto, S., Sakai, T., Takano, T., Miyazaki, Y., Imamura, A., & Ogino, K. (1988). Metabolism of chloral hydrate in the anoxic perfused liver. Toxicology Letters, 40(3), 225-231. https://doi.org/10.1016/0378-4274(88)90045-8