Metabolic competition in tumor microenvironment

Shingo Eikawa, Heiichiro Udono

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Metabolic pathways tightly regulate T cell response in host defense against infection and cancer. Glycolysis plays a key role in effector T cell differentiation and its function. More recent studies have demonstrated that tumor microenvironment forms hypoxia and metabolic disadvantage of immune cells. These environmental attributions impair the effector T cell survival, proliferation and function. Therefore repurposing of metabolic drugs might develop a novel cancer immunotherapy based on the targeting of T cell immunometabolism. In this review, we abridge basis of cancer cell and T cell metabolism and discuss recent advances elucidating "metabolic competition" exerted on tumor-infiltrating T cells that drive their dysfunction in tumor microenvironment.

Original languageEnglish
Pages (from-to)972-976
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume44
Issue number11
Publication statusPublished - Nov 2017

Keywords

  • Effector T cell
  • Glucose metabolism
  • Metabolic competition

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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