Metabolic competition in tumor microenvironment

Shingo Eikawa, Heiichiro Udono

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Metabolic pathways tightly regulate T cell response in host defense against infection and cancer. Glycolysis plays a key role in effector T cell differentiation and its function. More recent studies have demonstrated that tumor microenvironment forms hypoxia and metabolic disadvantage of immune cells. These environmental attributions impair the effector T cell survival, proliferation and function. Therefore repurposing of metabolic drugs might develop a novel cancer immunotherapy based on the targeting of T cell immunometabolism. In this review, we abridge basis of cancer cell and T cell metabolism and discuss recent advances elucidating "metabolic competition" exerted on tumor-infiltrating T cells that drive their dysfunction in tumor microenvironment.

Original languageEnglish
Pages (from-to)972-976
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume44
Issue number11
Publication statusPublished - Nov 1 2017

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Tumor Microenvironment
T-Lymphocytes
Neoplasms
Drug Repositioning
Glycolysis
Metabolic Networks and Pathways
Immunotherapy
Cell Differentiation
Cell Survival
Cell Proliferation
Infection

Keywords

  • Effector T cell
  • Glucose metabolism
  • Metabolic competition

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Metabolic competition in tumor microenvironment. / Eikawa, Shingo; Udono, Heiichiro.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 44, No. 11, 01.11.2017, p. 972-976.

Research output: Contribution to journalArticle

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