Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis

Mayuko Hamada, Katja Schröder, Jay Bathia, Ulrich Kürn, Sebastian Fraune, Mariia Khalturina, Konstantin Khalturin, Chuya Shinzato, Nori Satoh, Thomas C.G. Bosch

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Many multicellular organisms rely on symbiotic associations for support of metabolic activity, protection, or energy. Understanding the mechanisms involved in controlling such interactions remains a major challenge. In an unbiased approach we identified key players that control the symbiosis between Hydra viridissima and its photosynthetic symbiont Chlorella sp. A99. We discovered significant up-regulation of Hydra genes encoding a phosphate transporter and glutamine synthetase suggesting regulated nutrition supply between host and symbionts. Interestingly, supplementing the medium with glutamine temporarily supports in vitro growth of the otherwise obligate symbiotic Chlorella, indicating loss of autonomy and dependence on the host. Genome sequencing of Chlorella sp. A99 revealed a large number of amino acid transporters and a degenerated nitrate assimilation pathway, presumably as consequence of the adaptation to the host environment. Our observations portray ancient symbiotic interactions as a codependent partnership in which exchange of nutrients appears to be the primary driving force.

Original languageEnglish
Article numbere35122
JournaleLife
Volume7
DOIs
Publication statusPublished - May 31 2018

Fingerprint

Phosphate Transport Proteins
Amino Acid Transport Systems
Chlorella
Glutamate-Ammonia Ligase
Gene encoding
Symbiosis
Nutrition
Glutamine
Nitrates
Hydra
Nutrients
Genes
Amino Acid Transport System L
Up-Regulation
Genome
Food
Growth

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Hamada, M., Schröder, K., Bathia, J., Kürn, U., Fraune, S., Khalturina, M., ... Bosch, T. C. G. (2018). Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis. eLife, 7, [e35122]. https://doi.org/10.7554/eLife.35122

Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis. / Hamada, Mayuko; Schröder, Katja; Bathia, Jay; Kürn, Ulrich; Fraune, Sebastian; Khalturina, Mariia; Khalturin, Konstantin; Shinzato, Chuya; Satoh, Nori; Bosch, Thomas C.G.

In: eLife, Vol. 7, e35122, 31.05.2018.

Research output: Contribution to journalArticle

Hamada, M, Schröder, K, Bathia, J, Kürn, U, Fraune, S, Khalturina, M, Khalturin, K, Shinzato, C, Satoh, N & Bosch, TCG 2018, 'Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis', eLife, vol. 7, e35122. https://doi.org/10.7554/eLife.35122
Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M et al. Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis. eLife. 2018 May 31;7. e35122. https://doi.org/10.7554/eLife.35122
Hamada, Mayuko ; Schröder, Katja ; Bathia, Jay ; Kürn, Ulrich ; Fraune, Sebastian ; Khalturina, Mariia ; Khalturin, Konstantin ; Shinzato, Chuya ; Satoh, Nori ; Bosch, Thomas C.G. / Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis. In: eLife. 2018 ; Vol. 7.
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