Merkel cell polyomavirus and Langerhans cell neoplasm

Ichiro Murakami, Noriko Wada, Junko Nakashima, Mitsuko Iguchi, Makoto Toi, Yumiko Hashida, Tomonori Higuchi, Masanori Daibata, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Yasushi Horie, Keiko Nagata, Kazuhiko Hayashi, Takashi Oka, Tadashi Yoshino, Toshihiko Imamura, Akira Morimoto, Shinsaku Imashuku, Jean GogusevFrancis Jaubert

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Background: The relationship between various external agents such as pollen, food, and infectious agents and human sensitivity exists and is variable depending upon individual's health conditions. For example, we believe that the pathogenetic potential of the Merkel cell polyomavirus (MCPyV), the resident virus in skin, is variable and depends from the degree of individual's reactivity. MCPyV as well as Epstein-Barr virus, which are normally connected with humans under the form of subclinical infection, are thought to be involved at various degrees in several neoplastic and inflammatory diseases. In this review, we cover two types of Langerhans cell neoplasms, the Langerhans cell sarcoma (LCS) and Langerhans cell histiocytosis (LCH), represented as either neoplastic or inflammatory diseases caused by MCPyV. Methods: We meta-analyzed both our previous analyses, composed of quantitative PCR for MCPyV-DNA, proteomics, immunohistochemistry which construct IL-17 endocrine model and interleukin-1 (IL-1) activation loop model, and other groups' data. Results: We have shown that there were subgroups associated with the MCPyV as a causal agent in these two different neoplasms. Comparatively, LCS, distinct from the LCH, is a neoplastic lesion (or sarcoma) without presence of inflammatory granuloma frequently observed in the elderly. LCH is a proliferative disease of Langerhans-like abnormal cells which carry mutations of genes involved in the RAS/MAPK signaling pathway. We found that MCPyV may be involved in the development of LCH. Conclusion: We hypothesized that a subgroup of LCS developed according the same mechanism involved in Merkel cell carcinoma pathogenesis. We proposed LCH developed from an inflammatory process that was sustained due to gene mutations. We hypothesized that MCPyV infection triggered an IL-1 activation loop that lies beneath the pathogenesis of LCH and propose a new triple-factor model.

Original languageEnglish
Article number49
JournalCell Communication and Signaling
Volume16
Issue number1
DOIs
Publication statusPublished - Aug 22 2018

Fingerprint

Merkel cell polyomavirus
Langerhans Cells
Langerhans Cell Histiocytosis
Langerhans Cell Sarcoma
Interleukin-1
Viruses
Genes
Chemical activation
Neoplasms
Interleukin-17
Skin
Cells
Health
Polyomavirus Infections
Merkel Cell Carcinoma
DNA
Mutation
Asymptomatic Infections
Pollen
Granuloma

Keywords

  • BRAF mutation
  • Interleukin-1 loop model
  • Interleukin-17
  • ITIH4
  • Langerhans cell histiocytosis
  • Langerhans cell neoplasm
  • Langerhans cell sarcoma
  • Merkel cell polyomavirus
  • RAS/MAPK signaling pathway
  • Triple-factor model

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Murakami, I., Wada, N., Nakashima, J., Iguchi, M., Toi, M., Hashida, Y., ... Jaubert, F. (2018). Merkel cell polyomavirus and Langerhans cell neoplasm. Cell Communication and Signaling, 16(1), [49]. https://doi.org/10.1186/s12964-018-0261-y

Merkel cell polyomavirus and Langerhans cell neoplasm. / Murakami, Ichiro; Wada, Noriko; Nakashima, Junko; Iguchi, Mitsuko; Toi, Makoto; Hashida, Yumiko; Higuchi, Tomonori; Daibata, Masanori; Matsushita, Michiko; Iwasaki, Takeshi; Kuwamoto, Satoshi; Horie, Yasushi; Nagata, Keiko; Hayashi, Kazuhiko; Oka, Takashi; Yoshino, Tadashi; Imamura, Toshihiko; Morimoto, Akira; Imashuku, Shinsaku; Gogusev, Jean; Jaubert, Francis.

In: Cell Communication and Signaling, Vol. 16, No. 1, 49, 22.08.2018.

Research output: Contribution to journalReview article

Murakami, I, Wada, N, Nakashima, J, Iguchi, M, Toi, M, Hashida, Y, Higuchi, T, Daibata, M, Matsushita, M, Iwasaki, T, Kuwamoto, S, Horie, Y, Nagata, K, Hayashi, K, Oka, T, Yoshino, T, Imamura, T, Morimoto, A, Imashuku, S, Gogusev, J & Jaubert, F 2018, 'Merkel cell polyomavirus and Langerhans cell neoplasm', Cell Communication and Signaling, vol. 16, no. 1, 49. https://doi.org/10.1186/s12964-018-0261-y
Murakami I, Wada N, Nakashima J, Iguchi M, Toi M, Hashida Y et al. Merkel cell polyomavirus and Langerhans cell neoplasm. Cell Communication and Signaling. 2018 Aug 22;16(1). 49. https://doi.org/10.1186/s12964-018-0261-y
Murakami, Ichiro ; Wada, Noriko ; Nakashima, Junko ; Iguchi, Mitsuko ; Toi, Makoto ; Hashida, Yumiko ; Higuchi, Tomonori ; Daibata, Masanori ; Matsushita, Michiko ; Iwasaki, Takeshi ; Kuwamoto, Satoshi ; Horie, Yasushi ; Nagata, Keiko ; Hayashi, Kazuhiko ; Oka, Takashi ; Yoshino, Tadashi ; Imamura, Toshihiko ; Morimoto, Akira ; Imashuku, Shinsaku ; Gogusev, Jean ; Jaubert, Francis. / Merkel cell polyomavirus and Langerhans cell neoplasm. In: Cell Communication and Signaling. 2018 ; Vol. 16, No. 1.
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AU - Toi, Makoto

AU - Hashida, Yumiko

AU - Higuchi, Tomonori

AU - Daibata, Masanori

AU - Matsushita, Michiko

AU - Iwasaki, Takeshi

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