Mechanomedicine

Research output: Contribution to journalReview article

Abstract

It has been a long time since the term mechanobiology became widely accepted, and broad research approaches, ranging from basic biology to medical research, have been conducted from the perspective of mechanobiology. Our group created the term “mechanomedicine” focusing on the field encompassing studies of the pathology and treatment of various diseases based on the knowledge obtained from mechanobiological studies and have promoted studies in this field. In the respiratory and cardiovascular systems, not only humoral factors but also physical factors such as contraction and expansion phenomena, and feedback from such phenomena to tissues and cells are important stimuli for maintaining homeostasis. Loss of homeostasis is considered to lead to pathological conditions. This review aims to provide an overview of mechanomedicine by introducing several mechanosensitive channels including one particular type of mechanosensor that we discovered in the cardiovascular system and by describing stretchable three-dimensional cell culture scaffolds using self-assembled peptides, a highly motile sperm sorter using a sperm sorting technique based on microfluidic mechanics, and a device to promote the development of fertilized ova.

Original languageEnglish
Pages (from-to)1257-1262
Number of pages6
JournalBiophysical Reviews
Volume10
Issue number5
DOIs
Publication statusPublished - Oct 1 2018

Fingerprint

Biophysics
Cardiovascular System
Spermatozoa
Homeostasis
Microfluidics
Zygote
Mechanics
Respiratory System
Biomedical Research
Cell Culture Techniques
Pathology
Equipment and Supplies
Peptides
Research

Keywords

  • Hemostat
  • Mechanobiology
  • Microfluidic sperm sorter
  • SAKCA
  • Stretch-activated ion channel
  • TRPV2

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology

Cite this

Mechanomedicine. / Naruse, Keiji.

In: Biophysical Reviews, Vol. 10, No. 5, 01.10.2018, p. 1257-1262.

Research output: Contribution to journalReview article

Naruse, Keiji. / Mechanomedicine. In: Biophysical Reviews. 2018 ; Vol. 10, No. 5. pp. 1257-1262.
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