Mechanobiology in cardiac physiology and diseases

Ken Takahashi, Yoshihide Kakimoto, Kensaku Toda, Keiji Naruse

Research output: Contribution to journalReview articlepeer-review

43 Citations (Scopus)

Abstract

Mechanosensitivity is essential for heart function just as for all other cells and organs in the body, and it is involved in both normal physiology and diseases processes of the cardiovascular system. In this review, we have outlined the relationship between mechanosensitivity and heart physiology, including the Frank-Starling law of the heart and mechanoelectric feedback. We then focused on molecules involved in mechanotransduction, particularly mechanosensitive ion channels. We have also discussed the involvement of mechanosensitivity in heart diseases, such as arrhythmias, hypertrophy and ischaemic heart disease. Finally, mechanobiology in cardiogenesis is described with regard to regenerative medicine.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalJournal of Cellular and Molecular Medicine
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Arrhythmias
  • Cardiogenesis
  • Ischaemic/reperfusion injury
  • Mechanoelectric feedback
  • Mechanomedicine
  • Mechanosensitive ion channels
  • Mechanotransduction

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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