Mechanisms of progranulin action and regulation in genitourinary cancers

Ryuta Tanimoto; Kuojung G. Lu; Shi Qiong Xu; Simone Buraschi; Antonino Belfiore; Renato V. Iozzo; Andrea Morrione

doi:10.3389/fendo.2016.00100

Mechanisms of progranulin action and regulation in genitourinary cancers

Ryuta Tanimoto, Kuojung G. Lu, Shi Qiong Xu, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Andrea Morrione

Research output: Contribution to journal › Review article

8 Citations (Scopus)

Abstract

The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.

Original language	English
Article number	100
Journal	Frontiers in Endocrinology
Volume	7
Issue number	JUL
DOIs	https://doi.org/10.3389/fendo.2016.00100
Publication status	Published - Jul 27 2016
Externally published	Yes

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Keywords

Anchorage-independent growth
Bladder and prostate cancer
Motility
Progranulin
Tumor formation in vivo

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

Cite this

Tanimoto, R., Lu, K. G., Xu, S. Q., Buraschi, S., Belfiore, A., Iozzo, R. V., & Morrione, A. (2016). Mechanisms of progranulin action and regulation in genitourinary cancers. Frontiers in Endocrinology, 7(JUL), [100]. https://doi.org/10.3389/fendo.2016.00100

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10.3389/fendo.2016.00100