Abstract
The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.
| Original language | English |
|---|---|
| Article number | 100 |
| Journal | Frontiers in Endocrinology |
| Volume | 7 |
| Issue number | JUL |
| DOIs | |
| Publication status | Published - Jul 27 2016 |
| Externally published | Yes |
Keywords
- Anchorage-independent growth
- Bladder and prostate cancer
- Motility
- Progranulin
- Tumor formation in vivo
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
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Cite this
Tanimoto, R., Lu, K. G., Xu, S. Q., Buraschi, S., Belfiore, A., Iozzo, R. V., & Morrione, A. (2016). Mechanisms of progranulin action and regulation in genitourinary cancers. Frontiers in Endocrinology, 7(JUL), [100]. https://doi.org/10.3389/fendo.2016.00100