TY - JOUR
T1 - Mechanisms of progranulin action and regulation in genitourinary cancers
AU - Tanimoto, Ryuta
AU - Lu, Kuojung G.
AU - Xu, Shi Qiong
AU - Buraschi, Simone
AU - Belfiore, Antonino
AU - Iozzo, Renato V.
AU - Morrione, Andrea
N1 - Funding Information:
This work was supported in part by the Benjamin Perkins Bladder Cancer Fund, The Schorsch Family Fund for Innovative Medical Research and Care (AM), and National Institutes of Health Grants RO1 CA164462 (AM and RVI), and grants from the Associazione Italiana per la Ricerca sul Cancro (AIRC) (IG 14066/2013 to AB).
PY - 2016/7/27
Y1 - 2016/7/27
N2 - The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.
AB - The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.
KW - Anchorage-independent growth
KW - Bladder and prostate cancer
KW - Motility
KW - Progranulin
KW - Tumor formation in vivo
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U2 - 10.3389/fendo.2016.00100
DO - 10.3389/fendo.2016.00100
M3 - Review article
AN - SCOPUS:84982286591
VL - 7
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
IS - JUL
M1 - 100
ER -