Mechanisms of endogenous endothelial repair in stroke

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Recent evidence indicates that circulating endothelial progenitor cells can play an important role, not only in endothelium homeostasis of the pre-stroke brain, but also in angiogenesis of the post-stroke brain. Circulating endothelial progenitor cells are considered to repair endothelial cells by incorporating them into newly formed vessels, or by releasing pro-angiogenic factors. The number or function of circulating endothelial progenitor cells can be modulated by various kinds of factors. For example, elevated serum cholesterol, hypertension, diabetes and smoking decreased the number whereas vascular endothelial growth factor (VEGF), exercise, and statins can increase it. In this review, we discuss the present knowledge of endogenous mechanisms for the repair of endothelial cells, and how to enhance their possible capacity to remodel vascular units as neuronal self-repair strategies.

Original languageEnglish
Pages (from-to)3649-3652
Number of pages4
JournalCurrent Pharmaceutical Design
Volume18
Issue number25
DOIs
Publication statusPublished - 2012

Fingerprint

Stroke
Endothelial Cells
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Angiogenesis Inducing Agents
Brain
Hypercholesterolemia
Vascular Endothelial Growth Factor A
Endothelium
Blood Vessels
Homeostasis
Smoking
Hypertension
Serum
Endothelial Progenitor Cells

Keywords

  • Angiogenesis
  • Endothelial progenitor cells
  • Statin
  • Stroke
  • VEGF

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Mechanisms of endogenous endothelial repair in stroke. / Yamashita, Toru; Abe, Koji.

In: Current Pharmaceutical Design, Vol. 18, No. 25, 2012, p. 3649-3652.

Research output: Contribution to journalArticle

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