Abstract
Understanding and overcoming mechanisms of cancer escape from immunosurveillance have long been a major focus of cancer immunotherapy. These escape mechanisms are very complex, including cancer-derived factors, factors derived from host cells surrounding cancer nests, and factors derived through the interaction between cancer cells and host cells in the hypoxic state. This report mainly describes recent various immunosuppressive factors. Cancer immunotherapy will be best performed concomitantly with mechanisms blocking cancer escape.
| Original language | English |
|---|---|
| Pages (from-to) | 279-294 |
| Number of pages | 16 |
| Journal | Biotherapy |
| Volume | 18 |
| Issue number | 4 |
| Publication status | Published - Jul 2004 |
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Keywords
- Cancer escape
- Cancer immunotherapy
- Immunosurveillance
ASJC Scopus subject areas
- Cancer Research
- Immunology and Allergy
Cite this
Mechanisms of cancer escape from immunosurveillance. / Orita, Kunzo; Gochi, Akira; Nakamura, Shuji; Motoda, Ryuichi.
In: Biotherapy, Vol. 18, No. 4, 07.2004, p. 279-294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanisms of cancer escape from immunosurveillance
AU - Orita, Kunzo
AU - Gochi, Akira
AU - Nakamura, Shuji
AU - Motoda, Ryuichi
PY - 2004/7
Y1 - 2004/7
N2 - Understanding and overcoming mechanisms of cancer escape from immunosurveillance have long been a major focus of cancer immunotherapy. These escape mechanisms are very complex, including cancer-derived factors, factors derived from host cells surrounding cancer nests, and factors derived through the interaction between cancer cells and host cells in the hypoxic state. This report mainly describes recent various immunosuppressive factors. Cancer immunotherapy will be best performed concomitantly with mechanisms blocking cancer escape.
AB - Understanding and overcoming mechanisms of cancer escape from immunosurveillance have long been a major focus of cancer immunotherapy. These escape mechanisms are very complex, including cancer-derived factors, factors derived from host cells surrounding cancer nests, and factors derived through the interaction between cancer cells and host cells in the hypoxic state. This report mainly describes recent various immunosuppressive factors. Cancer immunotherapy will be best performed concomitantly with mechanisms blocking cancer escape.
KW - Cancer escape
KW - Cancer immunotherapy
KW - Immunosurveillance
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UR - http://www.scopus.com/inward/citedby.url?scp=4243070923&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:4243070923
VL - 18
SP - 279
EP - 294
JO - Biotherapy
JF - Biotherapy
SN - 0914-2223
IS - 4
ER -