Mechanisms of cancer escape from immunosurveillance

Kunzo Orita, Akira Gochi, Shuji Nakamura, Ryuichi Motoda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Understanding and overcoming mechanisms of cancer escape from immunosurveillance have long been a major focus of cancer immunotherapy. These escape mechanisms are very complex, including cancer-derived factors, factors derived from host cells surrounding cancer nests, and factors derived through the interaction between cancer cells and host cells in the hypoxic state. This report mainly describes recent various immunosuppressive factors. Cancer immunotherapy will be best performed concomitantly with mechanisms blocking cancer escape.

Original languageEnglish
Pages (from-to)279-294
Number of pages16
JournalBiotherapy
Volume18
Issue number4
Publication statusPublished - Jul 2004

Fingerprint

Immunologic Monitoring
Neoplasms
Immunotherapy
Immunosuppressive Agents

Keywords

  • Cancer escape
  • Cancer immunotherapy
  • Immunosurveillance

ASJC Scopus subject areas

  • Cancer Research
  • Immunology and Allergy

Cite this

Orita, K., Gochi, A., Nakamura, S., & Motoda, R. (2004). Mechanisms of cancer escape from immunosurveillance. Biotherapy, 18(4), 279-294.

Mechanisms of cancer escape from immunosurveillance. / Orita, Kunzo; Gochi, Akira; Nakamura, Shuji; Motoda, Ryuichi.

In: Biotherapy, Vol. 18, No. 4, 07.2004, p. 279-294.

Research output: Contribution to journalArticle

Orita, K, Gochi, A, Nakamura, S & Motoda, R 2004, 'Mechanisms of cancer escape from immunosurveillance', Biotherapy, vol. 18, no. 4, pp. 279-294.
Orita K, Gochi A, Nakamura S, Motoda R. Mechanisms of cancer escape from immunosurveillance. Biotherapy. 2004 Jul;18(4):279-294.
Orita, Kunzo ; Gochi, Akira ; Nakamura, Shuji ; Motoda, Ryuichi. / Mechanisms of cancer escape from immunosurveillance. In: Biotherapy. 2004 ; Vol. 18, No. 4. pp. 279-294.
@article{e372b65aed914df683bb1196bf4ab8bf,
title = "Mechanisms of cancer escape from immunosurveillance",
abstract = "Understanding and overcoming mechanisms of cancer escape from immunosurveillance have long been a major focus of cancer immunotherapy. These escape mechanisms are very complex, including cancer-derived factors, factors derived from host cells surrounding cancer nests, and factors derived through the interaction between cancer cells and host cells in the hypoxic state. This report mainly describes recent various immunosuppressive factors. Cancer immunotherapy will be best performed concomitantly with mechanisms blocking cancer escape.",
keywords = "Cancer escape, Cancer immunotherapy, Immunosurveillance",
author = "Kunzo Orita and Akira Gochi and Shuji Nakamura and Ryuichi Motoda",
year = "2004",
month = "7",
language = "English",
volume = "18",
pages = "279--294",
journal = "Biotherapy",
issn = "0914-2223",
publisher = "Japanese Society for Cancer Chemotherapy",
number = "4",

}

TY - JOUR

T1 - Mechanisms of cancer escape from immunosurveillance

AU - Orita, Kunzo

AU - Gochi, Akira

AU - Nakamura, Shuji

AU - Motoda, Ryuichi

PY - 2004/7

Y1 - 2004/7

N2 - Understanding and overcoming mechanisms of cancer escape from immunosurveillance have long been a major focus of cancer immunotherapy. These escape mechanisms are very complex, including cancer-derived factors, factors derived from host cells surrounding cancer nests, and factors derived through the interaction between cancer cells and host cells in the hypoxic state. This report mainly describes recent various immunosuppressive factors. Cancer immunotherapy will be best performed concomitantly with mechanisms blocking cancer escape.

AB - Understanding and overcoming mechanisms of cancer escape from immunosurveillance have long been a major focus of cancer immunotherapy. These escape mechanisms are very complex, including cancer-derived factors, factors derived from host cells surrounding cancer nests, and factors derived through the interaction between cancer cells and host cells in the hypoxic state. This report mainly describes recent various immunosuppressive factors. Cancer immunotherapy will be best performed concomitantly with mechanisms blocking cancer escape.

KW - Cancer escape

KW - Cancer immunotherapy

KW - Immunosurveillance

UR - http://www.scopus.com/inward/record.url?scp=4243070923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4243070923&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:4243070923

VL - 18

SP - 279

EP - 294

JO - Biotherapy

JF - Biotherapy

SN - 0914-2223

IS - 4

ER -