Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats

Chiaki Kamei, Masaya Ohuchi, Yukio Sugimoto, Chihiro Okuma

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In the present study, we have demonstrated that multiple first-generation H1-antagonists caused behavioral and EEG seizures in rats. The epileptogenic property of pyrilamine was more potent than either chlorpheniramine or diphenhydramine. In contrast, the second-generation H1-antagonists, loratadine and ebastine did not induce detectable epileptogenic activity. Intraperitoneal injection of histidine inhibited the EEG seizures induced by pyrilamine, diphenhydramine or chlorpheniramine; however no antagonism was observed with physostigmine. These results clearly suggest that the epileptogenic activity of first-generation H1-antagonists is dependent upon a centrally acting histaminergic mechanism.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalBrain Research
Volume887
Issue number1
DOIs
Publication statusPublished - Dec 22 2000

Fingerprint

Histamine H1 Antagonists
Chlorpheniramine
Pyrilamine
Diphenhydramine
Electroencephalography
Seizures
Non-Sedating Histamine H1 Antagonists
Loratadine
Physostigmine
Intraperitoneal Injections
Histidine
ebastine

Keywords

  • Chlorpheniramine
  • Diphenhydramine
  • Epileptogenic activity
  • Histidine
  • Physostigmine
  • Pyrilamine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats. / Kamei, Chiaki; Ohuchi, Masaya; Sugimoto, Yukio; Okuma, Chihiro.

In: Brain Research, Vol. 887, No. 1, 22.12.2000, p. 183-186.

Research output: Contribution to journalArticle

Kamei, Chiaki ; Ohuchi, Masaya ; Sugimoto, Yukio ; Okuma, Chihiro. / Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats. In: Brain Research. 2000 ; Vol. 887, No. 1. pp. 183-186.
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