Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats

Chiaki Kamei; Masaya Ohuchi; Yukio Sugimoto; Chihiro Okuma

doi:10.1016/S0006-8993(00)03041-9

Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats

Chiaki Kamei, Masaya Ohuchi, Yukio Sugimoto, Chihiro Okuma

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

In the present study, we have demonstrated that multiple first-generation H1-antagonists caused behavioral and EEG seizures in rats. The epileptogenic property of pyrilamine was more potent than either chlorpheniramine or diphenhydramine. In contrast, the second-generation H1-antagonists, loratadine and ebastine did not induce detectable epileptogenic activity. Intraperitoneal injection of histidine inhibited the EEG seizures induced by pyrilamine, diphenhydramine or chlorpheniramine; however no antagonism was observed with physostigmine. These results clearly suggest that the epileptogenic activity of first-generation H1-antagonists is dependent upon a centrally acting histaminergic mechanism.

Original language	English
Pages (from-to)	183-186
Number of pages	4
Journal	Brain Research
Volume	887
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(00)03041-9
Publication status	Published - Dec 22 2000

Keywords

Chlorpheniramine
Diphenhydramine
Epileptogenic activity
Histidine
Physostigmine
Pyrilamine

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)03041-9

Cite this

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abstract = "In the present study, we have demonstrated that multiple first-generation H1-antagonists caused behavioral and EEG seizures in rats. The epileptogenic property of pyrilamine was more potent than either chlorpheniramine or diphenhydramine. In contrast, the second-generation H1-antagonists, loratadine and ebastine did not induce detectable epileptogenic activity. Intraperitoneal injection of histidine inhibited the EEG seizures induced by pyrilamine, diphenhydramine or chlorpheniramine; however no antagonism was observed with physostigmine. These results clearly suggest that the epileptogenic activity of first-generation H1-antagonists is dependent upon a centrally acting histaminergic mechanism.",

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AU - Kamei, Chiaki

AU - Ohuchi, Masaya

AU - Sugimoto, Yukio

AU - Okuma, Chihiro

PY - 2000/12/22

Y1 - 2000/12/22

N2 - In the present study, we have demonstrated that multiple first-generation H1-antagonists caused behavioral and EEG seizures in rats. The epileptogenic property of pyrilamine was more potent than either chlorpheniramine or diphenhydramine. In contrast, the second-generation H1-antagonists, loratadine and ebastine did not induce detectable epileptogenic activity. Intraperitoneal injection of histidine inhibited the EEG seizures induced by pyrilamine, diphenhydramine or chlorpheniramine; however no antagonism was observed with physostigmine. These results clearly suggest that the epileptogenic activity of first-generation H1-antagonists is dependent upon a centrally acting histaminergic mechanism.

AB - In the present study, we have demonstrated that multiple first-generation H1-antagonists caused behavioral and EEG seizures in rats. The epileptogenic property of pyrilamine was more potent than either chlorpheniramine or diphenhydramine. In contrast, the second-generation H1-antagonists, loratadine and ebastine did not induce detectable epileptogenic activity. Intraperitoneal injection of histidine inhibited the EEG seizures induced by pyrilamine, diphenhydramine or chlorpheniramine; however no antagonism was observed with physostigmine. These results clearly suggest that the epileptogenic activity of first-generation H1-antagonists is dependent upon a centrally acting histaminergic mechanism.

KW - Chlorpheniramine

KW - Diphenhydramine

KW - Epileptogenic activity

KW - Histidine

KW - Physostigmine

KW - Pyrilamine

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Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats

Abstract

Keywords

ASJC Scopus subject areas

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